The kidney plays a primary role in maintaining homeostasis and detoxification of numerous
hydrophilic xenobiotics as well as endogenous compounds. Because the kidney is exposed …

Although it was long thought that opioid drugs act on specific receptor sites, opioid receptors
themselves were not identified until about 25 years ago (Pert and Snyder, 1973; Simon et al.…

Objective The potential influence of the multidrug resistance 1 (MDR1) gene and the cytochrome
P450 (CYP) genes, CYP3A4 and CYP3A5, on the oral clearance (CL/F) of tacrolimus in …

Ferroptosis is a recently recognized form of nonapoptotic cell death that is triggered by
reactive oxidative species (ROS) due to iron overload, lipid peroxidation accumulation, or the …

Drug-induced nephrotoxicity is a serious problem in patients with hospital-acquired acute
kidney injury (AKI). A new renal biomarker is needed because traditional markers are not …

The androgen receptor (AR) binds to and activates transcription of target genes in response
to androgens. In an attempt to isolate cofactors capable of influencing AR transcriptional …

Partial or complete obstruction of the urinary tract is a common and challenging urological
condition caused by a variety of conditions, including ureteral calculi, ureteral pelvic junction …

Because traditional markers for detecting renal injury are generally insensitive and nonspecific,
we tried to identify some useful biomarkers. Microarray analyses and quantitative real-…

This research was designed to determine the action of the novel aminoalkylindole AM630 (6-iodo-pravadoline)
at the cannabinoid receptor by studying its interaction with the …

What is known and objective Acute kidney injury ( AKI ) often occurs in hospitalized patients,
and it is an increasing problem worldwide. Recently, clinical studies have shown that there …