User profiles for Kimberly S. Collins
Kimberly S. CollinsSenior Quantitative Medicine Scientist Verified email at c-path.org Cited by 536 |
[HTML][HTML] Integration of spatial and single-cell transcriptomics localizes epithelial cell–immune cross-talk in kidney injury
Single-cell sequencing studies have characterized the transcriptomic signature of cell types
within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional …
within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional …
[HTML][HTML] The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline
…, H Gao, YL Liu, KS Collins, YH Cheng, S Winfree… - Elife, 2021 - elifesciences.org
Sepsis is a dynamic state that progresses at variable rates and has life-threatening
consequences. Staging patients along the sepsis timeline requires a thorough knowledge of the …
consequences. Staging patients along the sepsis timeline requires a thorough knowledge of the …
[HTML][HTML] The chromatin landscape of healthy and injured cell types in the human kidney
…, S Akilesh, R Ghag, C Lu, YH Cheng, KS Collins… - Nature …, 2024 - nature.com
There is a need to define regions of gene activation or repression that control human kidney
cells in states of health, injury, and repair to understand the molecular pathogenesis of …
cells in states of health, injury, and repair to understand the molecular pathogenesis of …
Molecular characterization of the human kidney interstitium in health and disease
…, S Winfree, MJ Ferkowicz, T Hato, KS Collins… - Science …, 2021 - science.org
The gene expression signature of the human kidney interstitium is incompletely understood.
The cortical interstitium (excluding tubules, glomeruli, and vessels) in reference …
The cortical interstitium (excluding tubules, glomeruli, and vessels) in reference …
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we
aggregated published meta-analyses of genome-wide association studies (GWAS), including …
aggregated published meta-analyses of genome-wide association studies (GWAS), including …
[HTML][HTML] C-peptide and metabolic outcomes in trials of disease modifying therapy in new-onset type 1 diabetes: an individual participant meta-analysis
PN Taylor, KS Collins, A Lam, SR Karpen… - The Lancet Diabetes & …, 2023 - thelancet.com
Background Metabolic outcomes in type 1 diabetes remain suboptimal. Disease modifying
therapy to prevent β-cell loss presents an alternative treatment framework but the effect on …
therapy to prevent β-cell loss presents an alternative treatment framework but the effect on …
Genotype-guided hydralazine therapy
KS Collins, ALJ Raviele, AL Elchynski… - American journal of …, 2020 - karger.com
Background: Despite its approval in 1953, hydralazine hydrochloride continues to be used
in the management of resistant hypertension, a condition frequently managed by …
in the management of resistant hypertension, a condition frequently managed by …
[HTML][HTML] Implementation of a renal precision medicine program: clinician attitudes and acceptance
…, PR Tripathy, AM Woodcock, NA Sheth, KS Collins… - Life, 2020 - mdpi.com
A precision health initiative was implemented across a multi-hospital health system, wherein
a panel of genetic variants was tested and utilized in the clinical care of chronic kidney …
a panel of genetic variants was tested and utilized in the clinical care of chronic kidney …
[HTML][HTML] Alterations in protein translation and carboxylic acid catabolic processes in diabetic kidney disease
KS Collins, MT Eadon, YH Cheng, D Barwinska… - Cells, 2022 - mdpi.com
Diabetic kidney disease (DKD) remains the leading cause of end-stage kidney disease despite
decades of study. Alterations in the glomerulus and kidney tubules both contribute to the …
decades of study. Alterations in the glomerulus and kidney tubules both contribute to the …
Enabling robotic pets to autonomously adapt their own behaviors to enhance therapeutic effects: a data-driven approach
Socially-assistive robots (SARs) hold significant potential to transform the management of
chronic healthcare conditions (eg diabetes, Alzheimer’s, dementia) outside the clinic walls. …
chronic healthcare conditions (eg diabetes, Alzheimer’s, dementia) outside the clinic walls. …