Natural substrates for alkaline phosphatase (AP) are at present not identified despite
extensive investigations. Difficulties in imagining a possible physiological function involve its …

Lipopolysaccharide (LPS) may cause sepsis when it enters the blood circulation. The toxic
moiety of LPS is the well-preserved lipid A part. Lipid A contains two phosphate groups …

Alkaline phosphatase (AP), a common enzyme present in many species including humans,
has been studied extensively. Although the enzyme is routinely applied as a marker for liver …

Many serious liver diseases affecting millions of people world-wide cannot be treated despite
many efforts which warrants a search for new therapeutic strategies. Potent drugs may not …

Background and aims: Crohn’s disease (CD) and ulcerative colitis (UC) are chronic
multifactorial inflammatory bowel diseases (IBDs) with unknown aetiology, but a deregulated …

The hallmark of liver fibrosis is an increased extracellular matrix deposition, caused by an
activation of hepatic stellate cells (HSC). Therefore, this cell type is an important target for …

Ursodeoxycholic acid (UDCA) is used in the treatment of cholestatic liver diseases, but its
mechanism of action is not yet well defined. The aim of this study was to explore the protective …

The inclusion complex formation of intravenously administered hydroxypropyl-β-cyclodextrin
and β-cyclodextrin with endogenous lipids was studied. We tested the hypothesis that …

Background/Aims: In acute liver failure, hepatocytes are exposed to various cytokines that
activate both cell survival and apoptotic pathways. NF-κB is a central transcription factor in …

The key pathogenic event in liver fibrosis is the activation of hepatic stellate cells (HSC).
Consequently, new antifibrotic therapies are directed toward an inhibition of HSC activities. The …