User profiles for Kodye L. Abbott

Kodye Abbott

Yale School of Medicine
Verified email at Yale.edu
Cited by 287

[HTML][HTML] Oroxylum Indicum ameliorates chemotherapy induced cognitive impairment

…, M Majrashi, M Almaghrabi, S Ramesh, KL Abbott… - Plos one, 2021 - journals.plos.org
While chemotherapy is the most effective therapeutic approach for treating a variety of cancer
patients, commonly used chemotherapeutic agents, often induce several adverse effects. …

Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR

SR Pondugula, PC Flannery, KL Abbott, ES Coleman… - Toxicology letters, 2015 - Elsevier
Activation of human pregnane X receptor (hPXR)-regulated expression of cytochrome P450
3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1) plays an important role in …

Cardioprotective Effects of Oroxylum indicum Extract Against Doxorubicin and Cyclophosphamide-Induced Cardiotoxicity

…, M Almaghrabi, M Majrashi, KL Abbott… - Cardiovascular …, 2022 - Springer
Administration of Chemotherapeutics, especially doxorubicin (DOX) and cyclophosphamide
(CPS), is commonly associated with adverse effects such as myelosuppression and …

IND-2, a pyrimido [1 ″, 2 ″: 1, 5] pyrazolo [3, 4-b] quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells

…, J Moore, R Mittal, EA Suswam, KL Abbott… - Bioorganic & medicinal …, 2015 - Elsevier
Naturally occurring condensed quinolines have anticancer properties. In efforts to find active
analogues, we designed and synthesized eight polycyclic heterocycles with a pyrimido[1″,…

Adverse pharmacokinetic interactions between illicit substances and clinical drugs

KL Abbott, PC Flannery, KS Gill, DM Boothe… - Drug Metabolism …, 2020 - Taylor & Francis
Adverse pharmacokinetic interactions between illicit substances and clinical drugs are of a
significant health concern. Illicit substances are taken by healthy individuals as well as by …

Pyrimido [1 ″, 2 ″: 1, 5] pyrazolo [3, 4-b] quinolines: Novel compounds that reverse ABCG2-mediated resistance in cancer cells

…, R Malla, CR Ashby Jr, H Amawi, KL Abbott… - Cancer letters, 2016 - Elsevier
Overexpression of ATP-binding cassette transporter (ABC) subfamily G2 in cancer cells is
known to elicit a MDR phenotype, ultimately resulting in cancer chemotherapy failure. Here, …

Belinostat, at its clinically relevant concentrations, inhibits rifampicin-induced CYP3A4 and MDR1 gene expression

KL Abbott, CS Chaudhury, A Chandran… - Molecular …, 2019 - ASPET
Activation of human pregnane X receptor (hPXR) has been associated with induction of
chemoresistance. It has been proposed that such chemoresistance via cytochrome P450/drug …

Correlation of PPM1A downregulation with CYP3A4 repression in the tumor liver tissue of hepatocellular carcinoma patients

PC Flannery, KL Abbott, SR Pondugula - European journal of drug …, 2020 - Springer
Background and Objective In many patients with hepatocellular carcinoma (HCC), cytochrome
P450 3A4 (CYP3A4) expression has been reported to be significantly reduced in the …

Interplay between the Cannabinoid system and microRNAs in cancer

JM Salamat, KL Abbott, PC Flannery, EL Ledbetter… - ACS …, 2022 - ACS Publications
Cancer patients often use cannabinoids for alleviating symptoms induced by cancer
pathogenesis and cancer treatment. This use of cannabinoids can have unexpected effects in …

Mg2+/Mn2+-Dependent Phosphatase 1A Is Involved in Regulating Pregnane X Receptor–Mediated Cytochrome p450 3A4 Gene Expression

…, T Geetha, SD Rege, T Chen, KL Abbott - Drug Metabolism and …, 2015 - ASPET
Variations in the expression of human pregnane X receptor (hPXR)–mediated cytochrome
p450 3A4 (CYP3A4) in liver can alter therapeutic response to a variety of drugs and may lead …