User profiles for Kodye L. Abbott
Kodye AbbottYale School of Medicine Verified email at Yale.edu Cited by 287 |
[HTML][HTML] Oroxylum Indicum ameliorates chemotherapy induced cognitive impairment
While chemotherapy is the most effective therapeutic approach for treating a variety of cancer
patients, commonly used chemotherapeutic agents, often induce several adverse effects. …
patients, commonly used chemotherapeutic agents, often induce several adverse effects. …
Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR
SR Pondugula, PC Flannery, KL Abbott, ES Coleman… - Toxicology letters, 2015 - Elsevier
Activation of human pregnane X receptor (hPXR)-regulated expression of cytochrome P450
3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1) plays an important role in …
3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1) plays an important role in …
Cardioprotective Effects of Oroxylum indicum Extract Against Doxorubicin and Cyclophosphamide-Induced Cardiotoxicity
Administration of Chemotherapeutics, especially doxorubicin (DOX) and cyclophosphamide
(CPS), is commonly associated with adverse effects such as myelosuppression and …
(CPS), is commonly associated with adverse effects such as myelosuppression and …
IND-2, a pyrimido [1 ″, 2 ″: 1, 5] pyrazolo [3, 4-b] quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells
Naturally occurring condensed quinolines have anticancer properties. In efforts to find active
analogues, we designed and synthesized eight polycyclic heterocycles with a pyrimido[1″,…
analogues, we designed and synthesized eight polycyclic heterocycles with a pyrimido[1″,…
Adverse pharmacokinetic interactions between illicit substances and clinical drugs
KL Abbott, PC Flannery, KS Gill, DM Boothe… - Drug Metabolism …, 2020 - Taylor & Francis
Adverse pharmacokinetic interactions between illicit substances and clinical drugs are of a
significant health concern. Illicit substances are taken by healthy individuals as well as by …
significant health concern. Illicit substances are taken by healthy individuals as well as by …
Pyrimido [1 ″, 2 ″: 1, 5] pyrazolo [3, 4-b] quinolines: Novel compounds that reverse ABCG2-mediated resistance in cancer cells
Overexpression of ATP-binding cassette transporter (ABC) subfamily G2 in cancer cells is
known to elicit a MDR phenotype, ultimately resulting in cancer chemotherapy failure. Here, …
known to elicit a MDR phenotype, ultimately resulting in cancer chemotherapy failure. Here, …
Belinostat, at its clinically relevant concentrations, inhibits rifampicin-induced CYP3A4 and MDR1 gene expression
KL Abbott, CS Chaudhury, A Chandran… - Molecular …, 2019 - ASPET
Activation of human pregnane X receptor (hPXR) has been associated with induction of
chemoresistance. It has been proposed that such chemoresistance via cytochrome P450/drug …
chemoresistance. It has been proposed that such chemoresistance via cytochrome P450/drug …
Correlation of PPM1A downregulation with CYP3A4 repression in the tumor liver tissue of hepatocellular carcinoma patients
PC Flannery, KL Abbott, SR Pondugula - European journal of drug …, 2020 - Springer
Background and Objective In many patients with hepatocellular carcinoma (HCC), cytochrome
P450 3A4 (CYP3A4) expression has been reported to be significantly reduced in the …
P450 3A4 (CYP3A4) expression has been reported to be significantly reduced in the …
Interplay between the Cannabinoid system and microRNAs in cancer
JM Salamat, KL Abbott, PC Flannery, EL Ledbetter… - ACS …, 2022 - ACS Publications
Cancer patients often use cannabinoids for alleviating symptoms induced by cancer
pathogenesis and cancer treatment. This use of cannabinoids can have unexpected effects in …
pathogenesis and cancer treatment. This use of cannabinoids can have unexpected effects in …
Mg2+/Mn2+-Dependent Phosphatase 1A Is Involved in Regulating Pregnane X Receptor–Mediated Cytochrome p450 3A4 Gene Expression
Variations in the expression of human pregnane X receptor (hPXR)–mediated cytochrome
p450 3A4 (CYP3A4) in liver can alter therapeutic response to a variety of drugs and may lead …
p450 3A4 (CYP3A4) in liver can alter therapeutic response to a variety of drugs and may lead …