N-Acetylcysteine—a safe antidote for cysteine/glutathione deficiency
KR Atkuri, JJ Mantovani, LA Herzenberg… - Current opinion in …, 2007 - Elsevier
Glutathione (GSH) deficiency is associated with numerous pathological conditions. Administration
of N-acetylcysteine (NAC), a cysteine prodrug, replenishes intracellular GSH levels. …
of N-acetylcysteine (NAC), a cysteine prodrug, replenishes intracellular GSH levels. …
Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal
The mechanism by which oxidative stress induces inflammation and vice versa is unclear but
is of great importance, being apparently linked to many chronic inflammatory diseases. We …
is of great importance, being apparently linked to many chronic inflammatory diseases. We …
Importance of culturing primary lymphocytes at physiological oxygen levels
KR Atkuri, LA Herzenberg, AK Niemi… - Proceedings of the …, 2007 - National Acad Sciences
Although studies with primary lymphocytes are almost always conducted in CO 2 incubators
maintained at atmospheric oxygen levels (atmosO 2 ; 20%), the physiological oxygen levels …
maintained at atmospheric oxygen levels (atmosO 2 ; 20%), the physiological oxygen levels …
Culturing at atmospheric oxygen levels impacts lymphocyte function
KR Atkuri, LA Herzenberg… - Proceedings of the …, 2005 - National Acad Sciences
To determine whether culturing peripheral blood mononuclear cells at atmospheric oxygen
levels skews responses in comparison with culturing lymphocytes at physiologic oxygen …
levels skews responses in comparison with culturing lymphocytes at physiologic oxygen …
Glut1-mediated glucose transport regulates HIV infection
…, LA Herzenberg, KR Atkuri… - Proceedings of the …, 2012 - National Acad Sciences
Cell cycle entry is commonly considered to positively regulate HIV-1 infection of CD4 T cells,
raising the question as to how quiescent lymphocytes, representing a large portion of the …
raising the question as to how quiescent lymphocytes, representing a large portion of the …
Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules
…, EEL Koster, EFE de Haas, KR Atkuri… - Proceedings of the …, 2006 - National Acad Sciences
Wnt signaling is essential for T cell development in the thymus, but the stages in which it
occurs and the molecular mechanisms underlying Wnt responsiveness have remained elusive. …
occurs and the molecular mechanisms underlying Wnt responsiveness have remained elusive. …
MYC Can Induce DNA Breaks In vivo and In vitro Independent of Reactive Oxygen Species
MYC overexpression is thought to initiate tumorigenesis by inducing cellular proliferation
and growth and to be restrained from causing tumorigenesis by inducing cell cycle arrest, …
and growth and to be restrained from causing tumorigenesis by inducing cell cycle arrest, …
Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia
KR Atkuri, TM Cowan, T Kwan, A Ng… - Proceedings of the …, 2009 - National Acad Sciences
Disorders affecting mitochondria, including those that directly affect the respiratory chain
function or result from abnormalities in branched amino acid metabolism (organic acidemias), …
function or result from abnormalities in branched amino acid metabolism (organic acidemias), …
Mass cytometry: a highly multiplexed single-cell technology for advancing drug development
KR Atkuri, JC Stevens, H Neubert - Drug Metabolism and Disposition, 2015 - ASPET
Advanced single-cell analysis technologies (eg, mass cytometry) that help in multiplexing
cellular measurements in limited-volume primary samples are critical in bridging discovery …
cellular measurements in limited-volume primary samples are critical in bridging discovery …
Nerve growth factor: a key local regulator in the pathogenesis of inflammatory arthritis
…, SK Raychaudhuri, KR Atkuri… - Arthritis & …, 2011 - Wiley Online Library
Objective The effect of nerve growth factor (NGF) and its receptor (NGFR) in inflammatory
diseases is a novel research field. The purpose of this study was to investigate the role of NGF/…
diseases is a novel research field. The purpose of this study was to investigate the role of NGF/…