N-Acetylcysteine—a safe antidote for cysteine/glutathione deficiency

KR Atkuri, JJ Mantovani, LA Herzenberg… - Current opinion in …, 2007 - Elsevier
Glutathione (GSH) deficiency is associated with numerous pathological conditions. Administration
of N-acetylcysteine (NAC), a cysteine prodrug, replenishes intracellular GSH levels. …

Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal

…, L Coppo, S Sacre, KR Atkuri… - Proceedings of the …, 2014 - National Acad Sciences
The mechanism by which oxidative stress induces inflammation and vice versa is unclear but
is of great importance, being apparently linked to many chronic inflammatory diseases. We …

Importance of culturing primary lymphocytes at physiological oxygen levels

KR Atkuri, LA Herzenberg, AK Niemi… - Proceedings of the …, 2007 - National Acad Sciences
Although studies with primary lymphocytes are almost always conducted in CO 2 incubators
maintained at atmospheric oxygen levels (atmosO 2 ; 20%), the physiological oxygen levels …

Culturing at atmospheric oxygen levels impacts lymphocyte function

KR Atkuri, LA Herzenberg… - Proceedings of the …, 2005 - National Acad Sciences
To determine whether culturing peripheral blood mononuclear cells at atmospheric oxygen
levels skews responses in comparison with culturing lymphocytes at physiologic oxygen …

Glut1-mediated glucose transport regulates HIV infection

…, LA Herzenberg, KR Atkuri… - Proceedings of the …, 2012 - National Acad Sciences
Cell cycle entry is commonly considered to positively regulate HIV-1 infection of CD4 T cells,
raising the question as to how quiescent lymphocytes, representing a large portion of the …

Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules

…, EEL Koster, EFE de Haas, KR Atkuri… - Proceedings of the …, 2006 - National Acad Sciences
Wnt signaling is essential for T cell development in the thymus, but the stages in which it
occurs and the molecular mechanisms underlying Wnt responsiveness have remained elusive. …

MYC Can Induce DNA Breaks In vivo and In vitro Independent of Reactive Oxygen Species

S Ray, KR Atkuri, D Deb-Basu, AS Adler, HY Chang… - Cancer research, 2006 - AACR
MYC overexpression is thought to initiate tumorigenesis by inducing cellular proliferation
and growth and to be restrained from causing tumorigenesis by inducing cell cycle arrest, …

Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia

KR Atkuri, TM Cowan, T Kwan, A Ng… - Proceedings of the …, 2009 - National Acad Sciences
Disorders affecting mitochondria, including those that directly affect the respiratory chain
function or result from abnormalities in branched amino acid metabolism (organic acidemias), …

Mass cytometry: a highly multiplexed single-cell technology for advancing drug development

KR Atkuri, JC Stevens, H Neubert - Drug Metabolism and Disposition, 2015 - ASPET
Advanced single-cell analysis technologies (eg, mass cytometry) that help in multiplexing
cellular measurements in limited-volume primary samples are critical in bridging discovery …

Nerve growth factor: a key local regulator in the pathogenesis of inflammatory arthritis

…, SK Raychaudhuri, KR Atkuri… - Arthritis & …, 2011 - Wiley Online Library
Objective The effect of nerve growth factor (NGF) and its receptor (NGFR) in inflammatory
diseases is a novel research field. The purpose of this study was to investigate the role of NGF/…