Chromium (III) tris (picolinate) is mutagenic at the hypoxanthine (guanine) phosphoribosyltransferase locus in Chinese hamster ovary cells
DM Stearns, SM Silveira, KK Wolf, AM Luke - Mutation Research/Genetic …, 2002 - Elsevier
Chromium trispicolinate (CrPic) is a popular dietary supplement that is not regulated by the
Food and Drug Administration. We are using this compound as a bio-available model to …
Food and Drug Administration. We are using this compound as a bio-available model to …
Subtoxic alterations in hepatocyte-derived exosomes: an early step in drug-induced liver injury?
NS Holman, M Mosedale, KK Wolf… - Toxicological …, 2016 - academic.oup.com
Drug-induced liver injury (DILI) is a significant clinical and economic problem in the United
States, yet the mechanisms that underlie DILI remain poorly understood. Recent evidence …
States, yet the mechanisms that underlie DILI remain poorly understood. Recent evidence …
A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models
AH Harrill, KD DeSmet, KK Wolf, AS Bridges… - Toxicological …, 2012 - academic.oup.com
DB289 is the first oral drug shown in clinical trials to have efficacy in treating African
trypanosomiasis (African sleeping sickness). Mild liver toxicity was noted but was not treatment …
trypanosomiasis (African sleeping sickness). Mild liver toxicity was noted but was not treatment …
miR-122 release in exosomes precedes overt tolvaptan-induced necrosis in a primary human hepatocyte micropatterned coculture model
…, OJ Trask Jr, NS Holman, KK Wolf… - Toxicological …, 2018 - academic.oup.com
Idiosyncratic drug-induced liver injury (IDILI) is thought to often result from an adaptive immune
attack on the liver. However, it has been proposed that the cascade of events culminating …
attack on the liver. However, it has been proposed that the cascade of events culminating …
Hepatocyte-derived exosomes promote liver immune tolerance: possible implications for idiosyncratic drug-induced liver injury
…, KA Rose, SE Thacker, MA Otieno, KK Wolf… - Toxicological …, 2019 - academic.oup.com
Most idiosyncratic drug-induced liver injury appears to result from an adaptive immune attack
on the liver. Recent evidence suggests that the T-cell response may be facilitated by the …
on the liver. Recent evidence suggests that the T-cell response may be facilitated by the …
Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport
KK Wolf, S Vora, LO Webster, GT Generaux, JW Polli… - Toxicology in Vitro, 2010 - Elsevier
Hepatocellular accumulation of bile acids due to inhibition of the canalicular bile salt export
pump (BSEP/ABCB11) is one proposed mechanism of drug-induced liver injury (DILI). Some …
pump (BSEP/ABCB11) is one proposed mechanism of drug-induced liver injury (DILI). Some …
Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity
KK Wolf, SG Wood, JA Hunt, BW Walton-Strong… - Drug metabolism and …, 2005 - ASPET
The pregnane X receptor (PXR) is a transcriptional regulator of xenobiotic metabolizing
enzymes, including cytochrome P450 3A (CYP3A), and transporters. Pretreatment of mice and …
enzymes, including cytochrome P450 3A (CYP3A), and transporters. Pretreatment of mice and …
Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1 (–/–) mice
KK Wolf, SG Wood, JL Allard, JA Hunt, N Gorman… - Drug metabolism and …, 2007 - ASPET
CYP2E1 is widely accepted as the sole form of cytochrome P450 responsible for alcohol-mediated
increases in acetaminophen (APAP) hepatotoxicity. However, we previously found …
increases in acetaminophen (APAP) hepatotoxicity. However, we previously found …
Characterization of Nonmutagenic Cr (III)− DNA Interactions
…, VH Coryell, BT Picard, KK Wolf… - Chemical research in …, 2003 - ACS Publications
Exposure of cells or animals to carcinogenic chromium(VI) (Cr(VI)) produces Cr(III)−DNA
adducts. The relevance of these lesions to Cr(VI)-induced tumors is unclear. Various Cr(III) …
adducts. The relevance of these lesions to Cr(VI)-induced tumors is unclear. Various Cr(III) …
[HTML][HTML] Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet …
JK Thuita, KK Wolf, GA Murilla, AS Bridges… - PLoS neglected …, 2015 - journals.plos.org
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected
tropical diseases based on limited availability of drugs that are safe and efficacious, …
tropical diseases based on limited availability of drugs that are safe and efficacious, …