Pharmacokinetics and biliary excretion of osaterone acetate, a new steroidal antiandrogen, in dogs

K Minato, N Koizumi, S Honma, K Tsukamoto… - Drug metabolism and …, 2002 - ASPET
The pharmacokinetics and biliary excretion of osaterone acetate (17α-acetoxy-6-chloro-2-oxa-4,6-pregnadiene-3,20-dione;
OA), a new steroidal antiandrogen, were investigated in …

Validation of an analytical method for a potent antitumor agent, TZT-1027, in plasma using liquid chromatography–mass spectrometry

…, K Araki, Y Kawabe, K Miyazaki, K Tsukamoto… - … of Chromatography B …, 2001 - Elsevier
A sensitive and specific analytical method for a potent antitumor agent, TZT-1027, in plasma
has been developed using liquid chromatography–mass spectrometry (LC–MS) with [ 2 H 4 ]…

Characterizations of mouse hepatic microsomal monooxygenase catalyzing 11β-hydroxylation of osaterone acetate

…, N Koizumi, S Honma, S Iwamura, K Tsukamoto - Biochemical …, 1999 - Elsevier
Osaterone acetate (17α-acetoxy-6-chloro-2-oxa-4,6-pregnadiene-3,20-dione, OA) is a new
steroidal antiandrogen. There is a marked species difference in the metabolism of OA in that …

Cytochrome P450 enzymes involved in the metabolic pathway of the histamine 2 (H2)-receptor antagonist roxatidine acetate by human liver microsomes

…, S Honma, S Iwamura, K Tsukamoto… - …, 2001 - thieme-connect.com
Roxatidine acetate hydrochloride (ROX, 2-acetoxy-N-[3-[m-(1-piperidinylmethyl) phenoxy]propyl]
acetamide hydrochloride, CAS 78273-80-0), a histamine 2 (H 2 ) -receptor antagonist, …

The metabolism of roxatidine acetate hydrochloride in rat and dog liver homogenates

…, K SHIBATA, Y KAWABE, K TSUKAMOTO… - Journal of …, 1987 - jstage.jst.go.jp
The metabolites were identified by gas chromatography-mass s ectrometry (GC-MS). When
an equimolar mixture of roxatidine acetate hydrochloride an its deuterated compound, …

Studies on the Metabolic Fate of Roxatidine Acetate Hydrochloride (10): Blood and Plasma Concentrations, Metabolism and Excretion after a Single Intravenous …

…, A FUJIKATA, Y KAWABE, K TSUKAMOTO… - Drug Metabolism and …, 1995 - jstage.jst.go.jp
2. Three metabolites, M-1, M-2 and M-3 were simultaneously determined by LC/MS-SIM in
dog plasma and urine. 3. Plasma concentration of M-1 reached the Cmax of 15.0 nmol/ml at …

Metabolic Fate of Roxatidine Acetate Hydrochloride (9): Blood and Plasma Concentration, Tissue Distribution and Excretion in Male Rat after a Single Intravenous …

…, Y KAWABE, S HONMA, K TSUKAMOTO - Drug Metabolism and …, 1995 - jstage.jst.go.jp
6) Only in the liver, the level of the phenolic metabolite, M-3, was the highest of the three
metabolites. This finding indicated that the metabolite might be main ly produced through …

[CITATION][C] Highly sensitive determination of 2-hydroxy-N-{3-[m-(1-piperidinylmethyl) phenoxy] propyl} acetamide (desacetyl TZU-0460) in rat plasma by high …

S Iwamura, K Tsukamoto - … of Chromatography B: Biomedical Sciences and …, 1987 - Elsevier
… SATOSHI IWAMURA* and KUNIO TSUKAMOTOTsukamoto, Pharmacometrics, 30 (1985)
329. … Tsukamoto, Pharmacometrics, 30 (1985) 299. …

[PDF][PDF] Shasei and Modern Tanka: A Comparison of Masaoka Shiki and Tsukamoto Kunio

A Houwen - Waseda Rilas Journal, 2020 - academia.edu
… ⑴ Some Japanese writers refer to Tsukamoto Kunio after the first mention as ‘Kunio’, … It
was in this context that Tsukamoto Kunio wrote the tanka collection Midoriiro kenkyū (‘A Study in …

A modern tanka poet Tsukamoto Kunio and the'Ryojin Hisho'songs

H Kobayashi - Journal of the Oriental Society of Australia, 1987 - search.informit.org
… In this paper, I should like Lo examine the works of Tsukamoto Kunio (b. 1922), a modem
poet, … , Tsukamoto's tanka present unique undertones, an echo of the songs from ancient days. …