Background: Omeprazole is metabolized by S-mephenytoin 4′-hydroxylase (CYP2C19) in
the liver. In persons with a poor-metabolizer genotype for CYP2C19, the therapeutic efficacy …

Objective Omeprazole is metabolized by genetically determined S‐mephenytoin 4′‐hydroxylase
(CYP2C19) in the liver. This study aimed to determine whether the effect of …

Background Proton pump inhibitors such as omeprazole and lansoprazole are mainly
metabolized by CYP2C19 in the liver. The therapeutic effects of proton pump inhibitors are …

Vascular endothelial cells are ubiquitous for their presence in each and every vessel and
unique for their multifunctional nature. A large number of endothelial functions depend to …

Objective The objective was to determine the effects of the SLCO2B1 c. 1457C> T polymorphism
and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans. …

Background and Objectives The acid‐inhibitory effect of lansoprazole depends on differences
in cytochrome P450 (CYP) 2C19 genotypes. We assessed whether therapeutic effects of …

This study was undertaken to clarify the influence of repeated oral administration of Ginkgo
biloba extract (GBE) on CYP2C9 and CYP3A4. CYP2C9 probe (tolbutamide, 125 mg) and …

Proton pump inhibitors (PPIs), such as omeprazole, lansoprazole, rabeprazole, esomeprazole,
and pantoprazole, are metabolized by cytochrome P450 isoenzyme 2C19 (CYP2C19) in …

Objective For the treatment of gastroesophageal reflux disease, intragastric pH should be
lower than 4.0 for no more than 4 hours a day (<16.7%). We aimed to develop optimal dosage …

3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are often prescribed
in association with antihypertensive agents, including calcium antagonists. Simvastatin is …