Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 …
K Köck, BC Ferslew, I Netterberg, K Yang… - Drug metabolism and …, 2014 - ASPET
Impaired hepatic bile acid export may contribute to development of cholestatic drug-induced
liver injury (DILI). The multidrug resistance-associated proteins (MRP) 3 and 4 are …
liver injury (DILI). The multidrug resistance-associated proteins (MRP) 3 and 4 are …
Up-regulation of UDP-glucuronosyltransferase (UGT) 1A4 by 17β-estradiol: a potential mechanism of increased lamotrigine elimination in pregnancy
H Chen, K Yang, S Choi, JH Fischer, H Jeong - Drug Metabolism and …, 2009 - ASPET
Oral clearance of lamotrigine, an antiepileptic drug commonly used in pregnant women, is
increased in pregnancy by unknown mechanisms. In this study, we show that 17β-estradiol (E …
increased in pregnancy by unknown mechanisms. In this study, we show that 17β-estradiol (E …
An updated review on drug-induced cholestasis: mechanisms and investigation of physicochemical properties and pharmacokinetic parameters
Drug-induced cholestasis is an important form of acquired liver disease and is associated
with significant morbidity and mortality. Bile acids are key signaling molecules, but they can …
with significant morbidity and mortality. Bile acids are key signaling molecules, but they can …
Systems pharmacology modeling predicts delayed presentation and species differences in bile acid–mediated troglitazone hepatotoxicity
K Yang, JL Woodhead, PB Watkins… - Clinical …, 2014 - Wiley Online Library
Troglitazone (TGZ) causes delayed, life‐threatening drug‐induced liver injury in some patients
but was not hepatotoxic in rats. This study investigated altered bile acid homeostasis as a …
but was not hepatotoxic in rats. This study investigated altered bile acid homeostasis as a …
Can bile salt export pump inhibition testing in drug discovery and development reduce liver injury risk? An international transporter consortium perspective
…, AD Rodrigues, PB Watkins, K Yang… - Clinical …, 2018 - Wiley Online Library
Bile salt export pump ( BSEP ) inhibition has emerged as an important mechanism that may
contribute to the initiation of human drug‐induced liver injury ( DILI ). Proactive evaluation …
contribute to the initiation of human drug‐induced liver injury ( DILI ). Proactive evaluation …
Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in …
ND Pfeifer, K Yang, KLR Brouwer - Journal of Pharmacology and …, 2013 - ASPET
Transporters responsible for hepatic uptake and biliary clearance (CL Bile ) of rosuvastatin (RSV)
have been well characterized. However, the contribution of basolateral efflux …
have been well characterized. However, the contribution of basolateral efflux …
[HTML][HTML] Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury
JL Woodhead, K Yang, SQ Siler, PB Watkins… - Frontiers in …, 2014 - frontiersin.org
Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced
liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver. We have …
liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver. We have …
Sandwich-cultured hepatocytes as a tool to study drug disposition and drug-induced liver injury
K Yang, C Guo, JL Woodhead, RLS Claire III… - Journal of …, 2016 - Elsevier
Sandwich-cultured hepatocytes (SCH) are metabolically competent and have proper localization
of basolateral and canalicular transporters with functional bile networks. Therefore, this …
of basolateral and canalicular transporters with functional bile networks. Therefore, this …
Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy
KH Koh, S Jurkovic, K Yang, SY Choi, JW Jung… - Biochemical …, 2012 - Elsevier
Pregnancy alters the rate and extent of drug metabolism, but little is known about the underlying
molecular mechanism. We have found that 17β-estradiol (E2) upregulates expression of …
molecular mechanism. We have found that 17β-estradiol (E2) upregulates expression of …
Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury
K Yang, ND Pfeifer, K Köck, KLR Brouwer - Journal of Pharmacology and …, 2015 - ASPET
The bile salt export pump (BSEP) plays an important role in bile acid excretion. Impaired
BSEP function may result in liver injury. Bile acids also undergo basolateral efflux, but the …
BSEP function may result in liver injury. Bile acids also undergo basolateral efflux, but the …