A guanine derivative with an acyclic side chain, 2-hydroxyethoxymethyl, at position 9 has
potent antiviral activity [dose for 50% inhibition (ED 50 ) = 0.1 μM] against herpes simplex virus …

… HJ Schaeffer, Lilia Beauchamp, P. de Miranda & Gertrude B. Elion, … e (l … Administration
of "C-acycloguanosine (50 mg per kg, sc) to groups of CD-l mice gave the tissue distribution …

… The L-amino acid esters were better prodrugs than the corresponding D- or D, L-isomers,
suggesting the involvement of a stereoselective transporter. The L-valyl ester, 256U87, was the …

Triggering of 2B4 (CD244) can induce natural killer (NK)-cell activation, costimulation, or
even inhibition of NK-cell activity. Here, we investigate the molecular basis for the different …

For many patients, numerous unpleasant features of the magnetic resonance imaging (MRI)
experience such as scan duration, auditory noise, spatial confinement, and motion …

The prodromal phase of Parkinson’s disease (PD) is characterised by many non-motor
symptoms, and these have recently been posited to be predictive of later diagnosis. Genetic …

Since the initial reports of COVID-19 in December 2019, the world has been gripped by the
disastrous acute respiratory disease caused by the SARS-CoV-2 virus. There are an ever-…

Acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] is an acyclic guanine nucleoside analogue
that is widely used clinically as an antiherpetic agent. Its limited absorption in humans after …

Our research sought to better understand the relationship between teacher professional
learning and teacher efficacy. The research was carried out from 2011 to 2013 in districts and …

Introduction Despite the efficacy of pre‐exposure prophylaxis (PrEP) in preventing HIV
transmission, few studies have evaluated PrEP use and retention in care outcomes in real‐world …