Context: Dutasteride and finasteride are 5α-reductase inhibitors (5ARIs) that dramatically
reduce serum levels of dihydrotestosterone (DHT). Objective: Because androgens are …

Prolongation of the QT interval has been observed with ondansetron and other members of
the 5‐HT 3 antagonist class. This is the first thorough QTc study of ondansetron conducted in …

(Headache 2010;50:357‐373) Objective.— To describe the pharmacokinetic and safety profiles
of sumatriptan 85 mg formulated with RT Technology (RT) and naproxen sodium 500 mg …

The present investigation was undertaken to examine the brain uptake kinetics of the central
nervous system (CNS) stimulant pentylenetetrazol (PTZ) during postnatal development. …

Purpose Until recently, ondansetron was approved for the prevention of nausea and
vomiting only in patients older than 2 years. However, as the use of ondansetron in patients …

Traumatic injury to both hard and soft tissue has been associated with a decrease in the rate
of hepatic drug metabolism. The mechanism(s) underlying this phenomenon have yet to be …

The dlsposftlon of valprolc acid (VPA) In serum and braIn tissue was #{149} xamlnedIn
developing rats (5, 10, 20, and 60 days postpartum) following both single and multlpi. …

Azathioprine (AZA) is used in the treatment of patients with refractory inflammatory bowel
disease; however, its use is limited because of systemic toxicity associated with long-term use. …

Purpose Vercirnon is a CCR9 chemokine receptor antagonist being developed for the
treatment of Crohn’s disease. As a variety of concomitant medications are often required for the …

Two randomized, single‐dose, crossover studies were carried out to assess different formulations
and doses of the CCR9 receptor antagonist vercirnon in healthy subjects. US study (n …