User profiles for L J Lee

Leo J. Lee

Senior Research Scientist, University of Toronto
Verified email at psi.toronto.edu
Cited by 10566

Receptor-targeted nanocarriers for therapeutic delivery to cancer

…, HC Tai, W Xue, LJ Lee, RJ Lee - Molecular membrane …, 2010 - Taylor & Francis
Efficient and site-specific delivery of therapeutic drugs is a critical challenge in clinical treatment
of cancer. Nano-sized carriers such as liposomes, micelles, and polymeric nanoparticles …

Stability, continence and breathing: the role of fascia following pregnancy and delivery

DG Lee, LJ Lee, L McLaughlin - Journal of bodywork and movement …, 2008 - Elsevier
… Reproduced with permission from Lee & Lee ©. … Reproduced with permission from Lee
& Lee ©. … Reproduced with permission from Lee & Lee ©. …

Current-generation high-throughput sequencing: deepening insights into mammalian transcriptomes

BJ Blencowe, S Ahmad, LJ Lee - Genes & development, 2009 - genesdev.cshlp.org
Recent papers have described the first application of high-throughput sequencing (HTS)
technologies to the characterization of transcriptomes. These studies emphasize the …

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

Q Pan, O Shai, LJ Lee, BJ Frey, BJ Blencowe - Nature genetics, 2008 - nature.com
We carried out the first analysis of alternative splicing complexity in human tissues using
mRNA-Seq data. New splice junctions were detected in ∼20% of multiexon genes, many of …

The human splicing code reveals new insights into the genetic determinants of disease

HY Xiong, B Alipanahi, LJ Lee, H Bretschneider… - Science, 2015 - science.org
INTRODUCTION Advancing whole-genome precision medicine requires understanding
how gene expression is altered by genetic variants, especially those that are far outside of …

The evolutionary landscape of alternative splicing in vertebrate species

…, M Irimia, Q Pan, HY Xiong, S Gueroussov, LJ Lee… - Science, 2012 - science.org
How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic
level is poorly understood. By comparing organ transcriptomes from vertebrate species …

Polymer nanocomposite foams

LJ Lee, C Zeng, X Cao, X Han, J Shen, G Xu - Composites science and …, 2005 - Elsevier
Polymer nanocomposite foams have received increasingly attention in both scientific and
industrial communities. The combination of functional nanoparticles and supercritical fluid …

A Review of CO2 Applications in the Processing of Polymers

…, H Li, D Liu, X Han, MJ Wingert, LJ Lee… - Industrial & …, 2003 - ACS Publications
The use of supercritical carbon dioxide as a processing solvent for the physical processing
of polymeric materials is reviewed. Fundamental properties of CO 2 /polymer systems are …

Deep learning of the tissue-regulated splicing code

MKK Leung, HY Xiong, LJ Lee, BJ Frey - Bioinformatics, 2014 - academic.oup.com
Motivation: Alternative splicing (AS) is a regulated process that directs the generation of
different transcripts from single genes. A computational model that can accurately predict …

Polyurethane/clay nanocomposites foams: processing, structure and properties

X Cao, LJ Lee, T Widya, C Macosko - Polymer, 2005 - Elsevier
Polyurethane (PU)/montmorillonite (MMT) nanocomposites were synthesized with
organically modified layered silicates (organoclays) by in situ polymerization and foams were …