Update on human herpesvirus 6 biology, clinical features, and therapy

L De Bolle, L Naesens, E De Clercq - Clinical microbiology …, 2005 - Am Soc Microbiol
… Dependency on viral DNA polymerase activity temporally discerns E and L proteins, although
exceptions (so called leaky transcripts) exist (318). Late proteins are often glycosylated …

Clinical features and treatment of adenovirus infections

…, E De Clercq, L Naesens - Reviews in medical …, 2008 - Wiley Online Library
… Adenovirus replication cycle The Ad replication cycle can be divided into an early (E) and
late (L) phase, according to the times at which particular viral genes are expressed. Shortly …

HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogues: a review of their pharmacology and clinical potential in the treatment of …

L Naesens, R Snoeck, G Andrei… - Antiviral Chemistry …, 1997 - journals.sagepub.com
The acyclic nucleoside phosphonate (ANP) analogues are broad-spectrum antiviral agents,
with potent and selective antiviral activity in vitro and in vivo. The prototype compounds are: (…

[HTML][HTML] Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial

…, U Smole, V Bosteels, L Hoste, L Naesens… - The Lancet …, 2021 - thelancet.com
… than 1000 μg/L, which had … μg/L; an increasing lactate dehydrogenase concentration of
more than 300 international units (IU)/L; an increasing CRP concentration of more than 70 mg/L; …

Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo …

J Balzarini, A Holy, J Jindrich, L Naesens… - Antimicrobial Agents …, 1993 - Am Soc Microbiol
… The enantiomeric purity of the products in the HPMP and FPMP series was verified by a
high-performance liquid chromatography technique (4 mM copper sulfate and 4 mM L-…

Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)‐1‐(3‐hydroxy‐2‐phosphonylmethoxypropyl) cytosine]

…, L Naesens, E De Clercq, L Feenstra - Journal of medical …, 1998 - Wiley Online Library
Respiratory papillomatosis is a rare and often severe disease, usually localized in the larynx.
It may cause respiratory distress and even life‐threatening obstruction of the airways. …

Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14

F Damian, N Blaton, L Naesens, J Balzarini… - European Journal of …, 2000 - Elsevier
… The HPLC system consisted of a LiChroGraph ® L-7100 HPLC pump, an autosampler
model L-7200 equipped with a 100 μl loop, a UV detector model L-7400 set at 297 nm, and an …

[HTML][HTML] TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

L Hoste, L Roels, L Naesens, V Bosteels… - Journal of Experimental …, 2022 - rupress.org
In rare instances, pediatric SARS-CoV-2 infection results in a novel immunodysregulation
syndrome termed multisystem inflammatory syndrome in children (MIS-C). We compared MIS-…

Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection

KJ Stittelaar, J Neyts, L Naesens, G Van Amerongen… - Nature, 2006 - nature.com
There is concern that variola virus, the aetiological agent of smallpox, may be used as a
biological weapon. For this reason several countries are now stockpiling (vaccinia virus-based) …

[HTML][HTML] The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways

…, M Hoffmann, P Maes, S Pöhlmann, L Naesens… - PLoS …, 2021 - journals.plos.org
… were shown to contain TMPRSS2, cathepsin B and cathepsin L. Calu-3 cells express
TMPRSS2 and a very low level of cathepsin L. The latter protease proved present at a very high …