An 800 compound hydantoin library has been constructed using a diverse set of 20 amino
acids and over 80 primary amines. Amino acids were attached via their N-termini to …

Cefaclor is a β-lactam antibiotic that degrades slowly under normal storage conditions to
several minor products. To obtain samples large enough to permit structure elucidation, …

Raloxifene (LY139481 HCl) is a selective estrogen receptor modulator (SERM) which blocks
the effects of estrogen on some tissues, such as the breast and uterus, while mimicking …

The four isomers of 4-aminopyrrolidine-2,4-dicarboxylate (APDC) were prepared and evaluated
for their effects at glutamate receptors in vitro. (2R,4R)-APDC (2a), an aza analog of the …

The metabolism and disposition of LY231514 was studied in mice and dogs. LY231514 is a
novel pyrrolopyrimidine-based multi-target antifolate (MTA) showing broad in vivo antitumor …

The aqueous acidic degradation of the oral cephalosporin cefaclor was investigated. A number
of degradation products were isolated and characterized. The degradation products can …

The acidic aqueous degradation of cefaclor, an orally administered cephalosporin antibiotic,
has been investigated. The most prominent peak in the high-performance liquid …

Tazofelone is a new inflammatory bowel disease agent. The biotransformation of tazofelone
in human livers and the cytochrome P450 responsible for the biotransformation has been …

The results of solvent-shift and hydrogen-bonding studies indicate that the (S)-sulphoxide
configuration can be assigned to the major sulphoxide oxidation products of Δ2- and Δ3-…

□ The aqueous degradation of the carbacephalosporin loracarbef under moderately acidic
conditions (pH range, 2.7 – 4.3) is described. Structures of a total of 10 compounds isolated …