The inflammatory response of mammalian cells to TNF-α can be switched to apoptosis either
by cotreatment with a protein synthesis inhibitor, cycloheximide, or Smac mimetic, a small …

Smac mimetics induce apoptosis synergistically with TNF-α by triggering the formation of a
caspase-8-activating complex containing receptor interacting protein kinase-1 (RIPK1). …

Germline mutations in the tumor suppressor gene, BRCA1, predispose individuals to breast
and ovarian cancers. Using a combination of affinity- and conventional chromatographic …

The receptor-interacting serine-threonine kinase 3 (RIP3) is a key signaling molecule in the
programmed necrosis (necroptosis) pathway. This pathway plays important roles in a variety …

A small-molecule mimetic of Smac/Diablo that specifically counters the apoptosis-inhibiting
activity of IAP proteins has been shown to enhance apoptosis induced by cell surface death …

OBJECTIVE: To investigate the efficacy and safety of selective head cooling with mild
systemic hypothermia in hypoxic-ischemic encephalopathy (HIE) in newborn infants. STUDY …

Photoelectron spectroscopy revealed that a 20-atom gold cluster has an extremely large
energy gap, which is even greater than that of C 60 , and an electron affinity comparable with …

Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope
glycoprotein are critical for viral evasion of antibody neutralization, and are themselves …

After the discovery of fullerene-C 60 , it took almost two decades for the possibility of boron-based
fullerene structures to be considered. So far, there has been no experimental evidence …

We report a joint experimental and theoretical study of the electronic and atomic structures of
small gold clusters with up to 14 atoms. Well-resolved photoelectron spectra were obtained …