User profiles for Lai Wang
Lai-Sheng WangProfessor of Chemistry, Brown University Verified email at brown.edu Cited by 50304 |
[HTML][HTML] TNF-α induces two distinct caspase-8 activation pathways
L Wang, F Du, X Wang - Cell, 2008 - cell.com
The inflammatory response of mammalian cells to TNF-α can be switched to apoptosis either
by cotreatment with a protein synthesis inhibitor, cycloheximide, or Smac mimetic, a small …
by cotreatment with a protein synthesis inhibitor, cycloheximide, or Smac mimetic, a small …
[HTML][HTML] Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-α
Smac mimetics induce apoptosis synergistically with TNF-α by triggering the formation of a
caspase-8-activating complex containing receptor interacting protein kinase-1 (RIPK1). …
caspase-8-activating complex containing receptor interacting protein kinase-1 (RIPK1). …
[HTML][HTML] BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer
Germline mutations in the tumor suppressor gene, BRCA1, predispose individuals to breast
and ovarian cancers. Using a combination of affinity- and conventional chromatographic …
and ovarian cancers. Using a combination of affinity- and conventional chromatographic …
[PDF][PDF] Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
The receptor-interacting serine-threonine kinase 3 (RIP3) is a key signaling molecule in the
programmed necrosis (necroptosis) pathway. This pathway plays important roles in a variety …
programmed necrosis (necroptosis) pathway. This pathway plays important roles in a variety …
[PDF][PDF] Autocrine TNFα signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
SL Petersen, L Wang, A Yalcin-Chin, L Li, M Peyton… - Cancer cell, 2007 - cell.com
A small-molecule mimetic of Smac/Diablo that specifically counters the apoptosis-inhibiting
activity of IAP proteins has been shown to enhance apoptosis induced by cell surface death …
activity of IAP proteins has been shown to enhance apoptosis induced by cell surface death …
Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China
…, R Shan, D Zhuang, L Du, Y Cao, Q Yang, L Wang… - The Journal of …, 2010 - Elsevier
OBJECTIVE: To investigate the efficacy and safety of selective head cooling with mild
systemic hypothermia in hypoxic-ischemic encephalopathy (HIE) in newborn infants. STUDY …
systemic hypothermia in hypoxic-ischemic encephalopathy (HIE) in newborn infants. STUDY …
Au20: A Tetrahedral Cluster
Photoelectron spectroscopy revealed that a 20-atom gold cluster has an extremely large
energy gap, which is even greater than that of C 60 , and an electron affinity comparable with …
energy gap, which is even greater than that of C 60 , and an electron affinity comparable with …
[HTML][HTML] Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope
glycoprotein are critical for viral evasion of antibody neutralization, and are themselves …
glycoprotein are critical for viral evasion of antibody neutralization, and are themselves …
Observation of an all-boron fullerene
After the discovery of fullerene-C 60 , it took almost two decades for the possibility of boron-based
fullerene structures to be considered. So far, there has been no experimental evidence …
fullerene structures to be considered. So far, there has been no experimental evidence …
On the Electronic and Atomic Structures of Small AuN- (N = 4−14) Clusters: A Photoelectron Spectroscopy and Density-Functional Study
We report a joint experimental and theoretical study of the electronic and atomic structures of
small gold clusters with up to 14 atoms. Well-resolved photoelectron spectra were obtained …
small gold clusters with up to 14 atoms. Well-resolved photoelectron spectra were obtained …