Genetic Variants in the UDP-glucuronosyltransferase 1A1 Gene Predict the Risk of Severe Neutropenia of Irinotecan
F Innocenti, SD Undevia, L Iyer, P Xian Chen… - Journal of Clinical …, 2004 - ascopubs.org
Purpose Severe toxicity is commonly observed in cancer patients receiving irinotecan. UDP-glucuronosyltransferase
1A1 (UGT1A1) catalyzes the glucuronidation of the active …
1A1 (UGT1A1) catalyzes the glucuronidation of the active …
Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active …
L Iyer, CD King, PF Whitington… - The Journal of …, 1998 - Am Soc Clin Investig
Irinotecan (CPT-11) is a promising antitumor agent, recently approved for use in patients
with metastatic colorectal cancer. Its active metabolite, SN-38, is glucuronidated by hepatic …
with metastatic colorectal cancer. Its active metabolite, SN-38, is glucuronidated by hepatic …
Phenotype‐genotype correlation of in vitro SN‐38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter …
L Iyer, D Hall, S Das, MA Mortell… - Clinical …, 1999 - Wiley Online Library
… Lalitha Iyer PhD… Lalitha Iyer PhD … Lalitha Iyer PhD …
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
…, KS Wickham, R Rochford, J Gahagen, L Iyer… - Science translational …, 2015 - science.org
Malaria is one of the most significant causes of childhood mortality, but disease control efforts
are threatened by resistance of the Plasmodium parasite to current therapies. Continued …
are threatened by resistance of the Plasmodium parasite to current therapies. Continued …
[HTML][HTML] A systematic screen of FDA-approved drugs for inhibitors of biological threat agents
…, TR Keepers, AC Shurtleff, CE Green, LV Iyer… - PloS one, 2013 - journals.plos.org
Background The rapid development of effective medical countermeasures against potential
biological threat agents is vital. Repurposing existing drugs that may have unanticipated …
biological threat agents is vital. Repurposing existing drugs that may have unanticipated …
Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7
F Innocenti, L Iyer, J Ramı́rez, MD Green… - Drug Metabolism and …, 2001 - ASPET
Epirubicin is one of the most active agents for breast cancer. The formation of epirubicin
glucuronide by liver UDP-glucuronosyltransferase (UGT) is its main inactivating pathway. This …
glucuronide by liver UDP-glucuronosyltransferase (UGT) is its main inactivating pathway. This …
A parallel chiral–achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of …
…, SLV Venkata, MJ Tanga, JE Bupp, CE Green, L Iyer… - Talanta, 2010 - Elsevier
A parallel chiral/achiral LC–MS/MS assay has been developed and validated to measure
the plasma and urine concentrations of the enantiomers of ketamine, (R)- and (S)-Ket, in …
the plasma and urine concentrations of the enantiomers of ketamine, (R)- and (S)-Ket, in …
Endoscopic placement of the small-bowel video capsule by using a capsule endoscope delivery device
…, M Reichelderfer, RH Judd, I Danko, LV Iyer… - Gastrointestinal …, 2007 - Elsevier
BACKGROUND: Capsule endoscopy performed via the traditional peroral route is technically
challenging in patients with dysphagia, gastroparesis, and/or abnormal upper-GI (UGI) …
challenging in patients with dysphagia, gastroparesis, and/or abnormal upper-GI (UGI) …
Lead Optimization of 3-Carboxyl-4(1H)-Quinolones to Deliver Orally Bioavailable Antimalarials
…, J Min, WA Guiguemde, A Pradhan, L Iyer… - Journal of Medicinal …, 2012 - ACS Publications
Malaria is a protozoal parasitic disease that is widespread in tropical and subtropical regions
of Africa, Asia, and the Americas and causes more than 800,000 deaths per year. The …
of Africa, Asia, and the Americas and causes more than 800,000 deaths per year. The …
Glucuronidation of trans‐resveratrol by human liver and intestinal microsomes and UGT isoforms
…, Y Li, AG Green, CE Green, LV Iyer… - Journal of pharmacy …, 2006 - Wiley Online Library
Resveratrol (trans‐resveratrol, trans‐3,5,4′‐trihydroxystilbene) is a naturally occurring
stilbene analogue found in high concentrations in red wine. There is considerable research …
stilbene analogue found in high concentrations in red wine. There is considerable research …