Background The rapid development of effective medical countermeasures against potential
biological threat agents is vital. Repurposing existing drugs that may have unanticipated …

BACKGROUND: Capsule endoscopy performed via the traditional peroral route is technically
challenging in patients with dysphagia, gastroparesis, and/or abnormal upper-GI (UGI) …

Resveratrol (trans‐resveratrol, trans‐3,5,4′‐trihydroxystilbene) is a naturally occurring
stilbene analogue found in high concentrations in red wine. There is considerable research …

We are continuing our concerted effort to optimize our first lead entry antagonist, NBD-11021,
which targets the Phe43 cavity of the HIV-1 envelope glycoprotein gp120, to improve …

Among the known antimalarial drugs, chloroquine (CQ) and other 4-aminoquinolines have
shown high potency and good bioavailability. Yet complications associated with drug …

Estragole (4-allyl-1-methoxybenzene) is a naturally occurring food flavoring agent found in
basil, fennel, bay leaves, and other spices. Estragole and its metabolite, 1′-…

The hydroxypyridinonate ligand 3,4,3-LI(1,2-HOPO) is currently under development for
radionuclide chelation therapy. The preclinical characterization of this highly promising ligand …

Compounds bactericidal against both replicating and nonreplicating Mtb may shorten the
length of TB treatment regimens by eliminating infections more rapidly. Screening of a panel of …

The purpose of this study was to investigate the sulfation of resveratrol (3,5,4′-trihydroxystilbene)
and its potential to exhibit drug-drug interactions via sulfation. The possible interaction …

Although cyclosporine (CSA) is established in the prevention of allograft rejection, its use has
been associated with dose-limiting toxicities, most notably to the kidney and liver. To date, …