User profiles for Laura Lowe Furge

Laura Furge

Kalamazoo College
Verified email at kzoo.edu
Cited by 1369

Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction

LL Furge, FP Guengerich - Biochemistry and Molecular Biology …, 2006 - Wiley Online Library
Cytochrome P450 (P450) enzymes include a family of related enzymes that are involved in
metabolism of vitamins, steroids, fatty acids, and other chemicals. This review presents a brief …

Inhibition of human cytochrome P450 enzymes by 1, 2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane

S Langouët, LL Furge, N Kerriguy… - Chemical research in …, 2000 - ACS Publications
Recent studies have demonstrated that two chemoprotective agents, oltipraz (OPZ), a
synthetic derivative of the natural compound 1,2-dithiole-3-thione (D3T), and sulforaphane (SF), …

Analysis of Nucleotide Insertion and Extension at 8-Oxo-7,8-dihydroguanine by Replicative T7 Polymerase exo- and Human Immunodeficiency Virus-1 Reverse …

LL Furge, FP Guengerich - Biochemistry, 1997 - ACS Publications
Pre-steady-state kinetics of incorporation of dCTP and dATP opposite site-specific 8-oxo-7,8-dihydroguanine
(8-oxoGua), in contrast to dCTP insertion opposite G, were examined as …

Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6

…, AK Bolles, LD Nagy, R Fujiwara, LL Furge - Xenobiotica, 2014 - Taylor & Francis
Metoclopramide is a widely used clinical drug in a variety of medical settings with rare acute
dystonic events reported. The aim of this study was to assess a previous report of …

[HTML][HTML] Molecular dynamics of CYP2D6 polymorphisms in the absence and presence of a mechanism-based inactivator reveals changes in local flexibility and …

PW de Waal, KF Sunden, LL Furge - PLoS One, 2014 - journals.plos.org
Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in
metabolism of many endogenous and exogenous small molecules. CYP2D6 is responsible …

Vertical and horizontal integration of bioinformatics education: a modular, interdisciplinary approach

LL Furge, R Stevens‐Truss, DB Moore… - Biochemistry and …, 2009 - Wiley Online Library
Bioinformatics education for undergraduates has been approached primarily in two ways:
introduction of new courses with largely bioinformatics focus or introduction of bioinformatics …

Explanation of Pre-Steady-State Kinetics and Decreased Burst Amplitude of HIV-1 Reverse Transcriptase at Sites of Modified DNA Bases with an Additional …

LL Furge, FP Guengerich - Biochemistry, 1999 - ACS Publications
The majority of pre-steady-state kinetic investigations with HIV-1 reverse transcriptase (HIV-1
RT) have reported substoichiometric bursts (30−50%) of product formation in the initial …

Oltipraz, 3H-1, 2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells

…, JA Chun, S Klenow, SC Larson, BB Haab, LL Furge - Toxicology letters, 2004 - Elsevier
Oltipraz (OPZ) is a known inducer of glutathione S-transferases and a mechanism-based
inhibitor of cytochrome P450 1A2. Given the detoxification characteristics of this compound, the …

Molecular analysis and modeling of inactivation of human CYP2D6 by four mechanism based inactivators

…, DJ Hsi, JM Holton, L Lowe Furge - Drug metabolism …, 2012 - ingentaconnect.com
Human cytochrome P450 2D6 (CYP2D6) is involved in metabolism of approximately 25% of
pharmaceutical drugs. Inactivation of CYP2D6 can lead to adverse drug interactions. Four …

Pre-Steady-State Kinetics of Nucleotide Insertion following 8-Oxo-7,8-dihydroguanine Base Pair Mismatches by Bacteriophage T7 DNA Polymerase exo-

LL Furge, FP Guengerich - Biochemistry, 1998 - ACS Publications
8-Oxo-7,8-dihydroguanine (8-oxoGua) can base pair with either cytosine (C) or adenine (A)
when replicated by DNA polymerases. The 8-oxoGua·A mismatch is extended in preference …