The analgesic acetaminophen causes a potentially fatal, hepatic centrilobular necrosis when
taken in overdose. The initial phases of toxicity were described in Dr. Gillette's laboratory in …

Although considered safe at therapeutic doses, at higher doses, acetaminophen produces a
centrilobular hepatic necrosis that can be fatal. Acetaminophen poisoning accounts for …

Large doses of the analgesic acetaminophen cause centrilobular hepatic necrosis in man
and in experimental animals. It has been previously shown that acetaminophen is …

The relationship between acetaminophen (APAP) reactive metabolite formation, nitrotyrosine
(NT) production, and cytokine elevation in APAP toxicity was investigated. Mice were …

Background & Aims: Acetaminophen toxicity is the most common cause of acute liver failure
(ALF) in the United States and Great Britain, but may be underrecognized in certain settings. …

Acetaminophen (APAP)-induced liver toxicity occurs with formation of APAP-protein adducts.
These adducts are formed by hepatic metabolism of APAP to N-acetyl-p-benzoquinone …

Abuse of synthetic cannabinoids (SCs), such as [1-naphthalenyl-(1-pentyl-1H-indol-3-yl]-methanone
(JWH-018) and [1-(5-fluoropentyl)-1H-indol-3-yl]-1-naphthalenyl-methanone (…

Acetaminophen-induced hepatotoxicity has been attributed to covalent binding of the
reactive metaboliteN-acetyl-p-benzoquinone imine to cysteine groups on proteins as an …

“K2/SPICE” products are commonly laced with aminoalkylindole synthetic cannabinoids (ie,
JWH-018 and JWH-073) and are touted as “legal” marijuana substitutes. Here we validate a …

Marijuana has been used recreationally and medicinally for centuries. The principle
psychoactive component, Δ 9-tetrahydrocannabinol (Δ 9-THC), activates CB1 cannabinoid …