Mesoporous silicon (PSi) microparticles were produced using thermal carbonization (TCPSi)
or thermal oxidation (TOPSi) to obtain surfaces suitable for oral drug administration …

Rapeseed, raspberry, and pine bark are promising bioactive sources of plant phenolics
selected from among ca. 100 previously screened plant materials for in vitro preclinical …

Biomembrane interactions of flavonoids and alkyl gallates were investigated using transport
studies on Caco-2 cells and membrane affinity experiments in phospholipid vesicles. …

Telaprevir 2 (VX-950), an inhibitor of the hepatitis C virus (HCV a ) NS3-4A protease, is in
phase 3 clinical trials. One of the major metabolites of 2 is its P1-(R)-diastereoisomer, 3 (VRT-…

While several therapeutic options exist, the need for more effective, safe, and convenient
treatment for a variety of autoimmune diseases persists. Targeting the Janus tyrosine kinases (…

The combined release and permeation behavior of furosemide loaded into thermally
carbonized mesoporous silicon (TCPSi) microparticles was studied in order to evaluate the …

Tutkimushankkeessa selvitettiin lähisuhdeväkivallan vaikutuksia terveys-, sosiaali-, ja
oikeuspalveluiden käyttöön sekä kustannuksiin. Tutkimuksessa kerättiin tietoa perus- ja …

Good reliability of Caco-2 permeability studies requires competent sampling and analytical
methods to ensure the comparability of day-to-day experiments. In this work, two n-in-one LC/…

Amprenavir (141W94, VX-478, KVX-478) is metabolized primarily by CYP3A4 (cytochrome
P450 3A4) in recombinant systems and human liver microsomes (HLM). The effects of …

The mRNA level expression of MDR1, MRP1-6, BCRP and CYP3A4 was determined by
quantitative PCR in wild type (Caco-2WT) and vinblastine-treated (Caco-2VBL) Caco-2 cells at …