Medetomidine (4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole) was tested for α 2 -adrenoceptor
agonist activity and compared to several reference agents. In binding studies carried out …

In view of conflicting data in the literature regarding the enzyme(s) responsible for metabolism
of selegiline, a drug used in the treatment of Parkinson's disease, investigations were …

Selegiline was used as a model compound in a project aimed at comparing, evaluating,
and integrating different in vitro approaches for the prediction of cytochrome P450 (P450)-…

: The short-term effect of 20 mg of oral nifedipine on maternal and fetal hemodynamics was
investigated in ten healthy, normotensive women at 38 weeks' gestation admitted to the …

Indirect experimental evidence suggests that drugs acting on the α 2C ‐adrenoceptor could
be useful in the treatment of neuropsychiatric disorders such as depression and …

Background Rifampin (INN, rifampicin) is a potent inducer of cytochrome P450 (CYP) enzymes
involved in drug metabolism and therefore causes many drug interactions. Methods The …

Although being a drug therapeutically used for a long time, the enzymatic metabolism of
selegiline has not been adequately studied. In the current work we have studied the cytochrome …

The in vitro receptor interactions of detomidine, a novel veterinary sedative analgesic, were
studied. Detomidine caused a concentration-dependent inhibition of the twitch response in …

Selegiline, an irreversible and selective inhibitor of monoamine oxidase type B (MAO‐B), is
metabolized into desmethylselegiline, levomethamphetamine, and levoamphetamine. In …

Objective: To characterise the effects of itraconazole, a potent inhibitor of CYP3A4, on the
pharmacokinetics of selegiline in healthy volunteers. Methods: In this randomised, placebo-…