Multi-well array culture of primary human hepatocyte spheroids for clearance extrapolation of slowly metabolized compounds
LC Preiss, VM Lauschke, K Georgi, C Petersson - The AAPS Journal, 2022 - Springer
Accurate prediction of human pharmacokinetics using in vitro tools is an important task during
drug development. Albeit, currently used in vitro systems for clearance extrapolation such …
drug development. Albeit, currently used in vitro systems for clearance extrapolation such …
[HTML][HTML] 3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation
… The authors declare the following financial interests/personal relationships which may be
considered as potential competing interests: Lena C. Preiss reports financial support was …
considered as potential competing interests: Lena C. Preiss reports financial support was …
[HTML][HTML] Bioengineered pancreas–liver crosstalk in a microfluidic coculture chip identifies human metabolic response signatures in prediabetic hyperglycemia
…, J Keulen, JX Shen, N Taebnia, LC Preiss… - Advanced …, 2022 - ncbi.nlm.nih.gov
Aberrant glucose homeostasis is the most common metabolic disturbance affecting one in
ten adults worldwide. Prediabetic hyperglycemia due to dysfunctional interactions between …
ten adults worldwide. Prediabetic hyperglycemia due to dysfunctional interactions between …
Bioengineered Pancreas–Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia
…, J Keulen, JX Shen, N Taebnia, LC Preiss… - Advanced …, 2022 - Wiley Online Library
Aberrant glucose homeostasis is the most common metabolic disturbance affecting one in
ten adults worldwide. Prediabetic hyperglycemia due to dysfunctional interactions between …
ten adults worldwide. Prediabetic hyperglycemia due to dysfunctional interactions between …
Deconvolution of cytochrome P450 induction mechanisms in HepaRG nuclear hormone receptor knockout cells
LC Preiss, R Liu, P Hewitt, D Thompson… - Drug Metabolism and …, 2021 - ASPET
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and PXR/CAR knockout
(KO) HepaRG cells, as well as a PXR reporter gene assay, were used to investigate the …
(KO) HepaRG cells, as well as a PXR reporter gene assay, were used to investigate the …
Comparison of Human Long-Term Liver Models for Clearance Prediction of Slowly Metabolized Compounds
LC Preiss, K Georgi, VM Lauschke… - Drug Metabolism and …, 2024 - ASPET
The accurate prediction of human clearance is an important task during drug development.
The proportion of low clearance compounds has increased in drug development pipelines …
The proportion of low clearance compounds has increased in drug development pipelines …
[BOOK][B] Exploration of Novel Hepatic in-vitro Systems for Drug Metabolism and Pharmacokinetic Studies
LC Preiss - 2023 - search.proquest.com
The development of a novel drug is a highly cost-intensive and risky process and many drug
candidates fail on the way to final approval. An important task during this development is to …
candidates fail on the way to final approval. An important task during this development is to …
On the “normalizing factor” for the tomato mutant chloronerva—XIV: Synthesis of the proline analogue of the phytosiderophore nicotianamine
J Faust, A Preiss, K Schreiber, H Ripperger - Tetrahedron, 1983 - Elsevier
… confirmed by “C NMR spectroscopy. especially by comparison with the “Cchemical shift data
of … Tk data CTable I) exhibit tk presence of thirteen C-atoms in tk proton noise decoupled “C …
of … Tk data CTable I) exhibit tk presence of thirteen C-atoms in tk proton noise decoupled “C …
[HTML][HTML] Bacterial microbiota diversity and composition in red and white wines correlate with plant-derived DNA contributions and botrytis infection
Wine is a globally produced, marketed and consumed alcoholic beverage, which is valued
for its aromatic and qualitative complexity and variation. These properties are partially …
for its aromatic and qualitative complexity and variation. These properties are partially …
Organotypic and microphysiological human tissue models for drug discovery and development—current state-of-the-art and future perspectives
The number of successful drug development projects has been stagnant for decades
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …