Evidence for polymorphism in the canine metabolism of the cyclooxygenase 2 inhibitor, celecoxib
SK Paulson, L Engel, B Reitz, S Bolten… - Drug metabolism and …, 1999 - ASPET
The pharmacokinetics of celecoxib, a cyclooxygenase-2 inhibitor, was characterized in beagle
dogs. Celecoxib is extensively metabolized by dogs to a hydroxymethyl metabolite with …
dogs. Celecoxib is extensively metabolized by dogs to a hydroxymethyl metabolite with …
Inhibition of neointimal hyperplasia by blocking αvβ3 integrin with a small peptide antagonist GpenGRGDSPCA
ET Choi, L Engel, AD Callow, S Sun… - Journal of vascular …, 1994 - Elsevier
Purpose: Neointimal hyperplasia is a leading cause of restenosis after vascular procedures.
Recent findings showed that smooth muscle cell (SMC) migration from the media into the …
Recent findings showed that smooth muscle cell (SMC) migration from the media into the …
TGF-β1 reverses PDGF-stimulated migration of human aortic smooth muscle cells in vitro
L Engel, U Ryan - In Vitro Cellular & Developmental Biology-Animal, 1997 - Springer
Platelet-derived growth factor (PDGF) and transforming growth factor beta-1(TGF-β1) were
tested separately or together for the ability to stimulate migration of human aortic vascular …
tested separately or together for the ability to stimulate migration of human aortic vascular …
Expression and characterization of functional dog flavin-containing monooxygenase 1
JC Stevens, RJ Melton, MJ Zaya, LC Engel - Molecular pharmacology, 2003 - ASPET
A full-length dog (beagle) flavin-containing monooxygenase 1 (FMO1) cDNA (dFMO1) was
obtained from liver by reverse transcription-polymerase chain reaction. The amino acid …
obtained from liver by reverse transcription-polymerase chain reaction. The amino acid …
Antibodies to 100-and 60-kDa surface proteins inhibit substratum attachment and differentiation of rodent skeletal myoblasts
L Engel, JM White - Developmental biology, 1990 - Elsevier
A rabbit polyclonal antiserum was raised against membrane vesicles shed from the surface
of fusing L6 rat myoblasts. In immunoblots the antiserum recognized fibronectin, a protein of …
of fusing L6 rat myoblasts. In immunoblots the antiserum recognized fibronectin, a protein of …
Temperature-sensitive nonfusing myoblast variant and spontaneous revertant: Isolation and characterization
LC Engel, JD David - Somatic cell and molecular genetics, 1985 - Springer
A stable, temperature-sensitive, nonfusing variant of the L 6 rat myoblast cell line has been
isolated following mild EMS-induced mutagenesis. At the permissive temperature (37 C), the …
isolated following mild EMS-induced mutagenesis. At the permissive temperature (37 C), the …
Medical Reserach Program Bulletin
EK Gallin, JC Fanzo, E Meyers, L Engel - 2005 - academiccommons.columbia.edu
David Nathan: I wasn’t interested in it at all when I was in medical school or as an intern. I
wanted to study liver disease. When I got to the NIH I was assigned to a laboratory. I sat down …
wanted to study liver disease. When I got to the NIH I was assigned to a laboratory. I sat down …
The Role of the α vB3 Integrin in Smooth Muscle Cell Migration
L Engel, E Choi, K Broschat, C Gorka, U Ryan… - … : Physiological Basis of …, 1993 - Springer
Intimal hyperplasia is a key event in advanced atherosclerotic lesions. Thickening of the
intimal layer of large muscular arteries may result from smooth muscle cells (SMC) that migrate …
intimal layer of large muscular arteries may result from smooth muscle cells (SMC) that migrate …
Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D
X Yang, H Song, G Leslie, C Engel… - JNCI: Journal of the …, 2020 - academic.oup.com
Background The purpose of this study was to estimate precise age-specific tubo-ovarian
carcinoma (TOC) and breast cancer (BC) risks for carriers of pathogenic variants in RAD51C …
carcinoma (TOC) and breast cancer (BC) risks for carriers of pathogenic variants in RAD51C …
[CITATION][C] Eric T. Choi, MD, Leslie Engel, PhD, Allan D. Callow, MD, Shaping Sun, MsSci, Jeffrey Trachtenberg, MD, Samuel Sanforo, MD, and Una S. Ryan, PhD …
MF Silane, KM Conte, GA Fantini, E Kazam - Journal of Vascular Surgery