AMG 176, a selective MCL1 inhibitor, is effective in hematologic cancer models alone and in combination with established therapies

…, D Chui, DA Whittington, X Huang, L Poppe… - Cancer discovery, 2018 - AACR
AMG 176 is a potent, selective, and orally bioavailable MCL1 inhibitor that induces a rapid
commitment to apoptosis in models of hematologic malignancies. The synergistic …

[HTML][HTML] Hepcidin revisited, disulfide connectivity, dynamics, and structure

JB Jordan, L Poppe, M Haniu, T Arvedson… - Journal of Biological …, 2009 - ASBMB
Hepcidin is a tightly folded 25-residue peptide hormone containing four disulfide bonds,
which has been shown to act as the principal regulator of iron homeostasis in vertebrates. We …

Conformation of sLex Tetrasaccharide, Free in Solution and Bound to E-, P-, and L-Selectin,

L Poppe, GS Brown, JS Philo, PV Nikrad… - Journal of the …, 1997 - ACS Publications
The conformations of the NeuAcα2(I)→3Galβ1(II)→4[Fucα1(III)→3]GlcNAc-O-CH 3
tetrasaccharide (sLe x ), in aqueous solution and bound to E-, P-, and L-selectin have been …

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

JK Murray, J Ligutti, D Liu, A Zou, L Poppe… - Journal of medicinal …, 2015 - ACS Publications
Na V 1.7 is a voltage-gated sodium ion channel implicated by human genetic evidence as a
therapeutic target for the treatment of pain. Screening fractionated venom from the tarantula …

Fragment Based Drug Discovery: Practical Implementation Based on 19F NMR Spectroscopy

JB Jordan, L Poppe, X Xia, AC Cheng… - Journal of medicinal …, 2012 - ACS Publications
Fragment based drug discovery (FBDD) is a widely used tool for discovering novel therapeutics.
NMR is a powerful means for implementing FBDD, and several approaches have been …

Profiling Formulated Monoclonal Antibodies by 1H NMR Spectroscopy

L Poppe, JB Jordan, K Lawson, M Jerums… - Analytical …, 2013 - ACS Publications
Nuclear magnetic resonance (NMR) is arguably the most direct methodology for characterizing
the higher-order structure of proteins in solution. Structural characterization of proteins by …

Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity

…, M Ma, H Li, MJ Rose, L Poppe… - Journal of medicinal …, 2008 - ACS Publications
A series of conformationally constrained derivatives of glucagon-like peptide-1 (GLP-1) were
designed and evaluated. By use of [Gly 8 ]GLP-1(7–37)-NH 2 (2) peptide as a starting point…

Three-dimensional structure of the oligosaccharide chain of GM1 ganglioside revealed by a distance-mapping procedure: a rotating and laboratory frame nuclear …

D Acquotti, L Poppe, J Dabrowski… - Journal of the …, 1990 - ACS Publications
Three-dimensional structure of the oligosaccharide partof the GMI ganglioside, Galj31-3GalNAc01-(NeuAca2-3)
4Gal/31-4Glc/31-lCer, was modeled with use of a distance-mapping …

The solution conformation of sialyl-α (2→ 6)-lactose studied by modern NMR techniques and Monte Carlo simulations

L Poppe, R Stuike-Prill, B Meyer… - Journal of biomolecular …, 1992 - Springer
We present a comprehensive strategy for detailed characterization of the solution
conformations of oligosaccharides by NMR spectroscopy and force-field calculations. Our …

Ordering of the N-terminus of human MDM2 by small molecule inhibitors

…, PD Schnier, X Huang, L Poppe - Journal of the …, 2012 - ACS Publications
Restoration of p53 function through the disruption of the MDM2-p53 protein complex is a
promising strategy for the treatment of various types of cancer. Here, we present kinetic, …