The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European–Americans

…, AL Hinrichs, JC Wang, LB Von Weymarn… - Pharmacogenetics …, 2011 - journals.lww.com
Objective To study the association between cytochrome P450 2A6 (CYP2A6) genotype and
metabolism of nicotine to cotinine, identify functional polymorphisms, and develop a …

Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers

LB Von Weymarn, JA Chun, PF Hollenberg - Carcinogenesis, 2006 - academic.oup.com
Isothiocyanates have been shown to be potent inhibitors of carcinogenesis in animals
exposed to a number of chemical carcinogens including the tobacco-specific nitrosamine 4-(…

Quantitation of the minor tobacco alkaloids nornicotine, anatabine, and anabasine in smokers' urine by high throughput liquid chromatography–mass spectrometry

LB Von Weymarn, NM Thomson… - Chemical research in …, 2016 - ACS Publications
Nicotine is the most abundant alkaloid in tobacco accounting for 95% of the alkaloid content.
There are also several minor tobacco alkaloids; among these are nornicotine, anatabine, …

Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism

LB Von Weymarn, KM Brown, SE Murphy - Journal of Pharmacology and …, 2006 - ASPET
… The CYP2A13 used in this study is the same preparation as that used by von Weymarn et
al. (2005). At saturating conditions of coumarin, the rate of coumarin 7-hydroxylation for both …

Quantitation of Ten Urinary Nicotine Metabolites, Including 4-Hydroxy-4-(3-pyridyl) Butanoic Acid, a Product of Nicotine 2′-Oxidation, and CYP2A6 Activity in …

LB von Weymarn, X Lu, NM Thomson… - Chemical research in …, 2023 - ACS Publications
Smoking intensity varies across smokers and is influenced by individual variability in the
metabolism of nicotine, the major addictive agent in tobacco. Therefore, lung cancer risk, which …

Inhibition and inactivation of cytochrome P450 2A6 and cytochrome P450 2A13 by menthofuran, β-nicotyrine and menthol

VM Kramlinger, LB von Weymarn, SE Murphy - Chemico-biological …, 2012 - Elsevier
Nicotine is the primary addictive agent in tobacco products and is metabolized in humans
by CYP2A6. Decreased CYP2A6 activity has been associated with decreased smoking. The …

Analysis of [3′, 3′-d2]-nicotine and [3′, 3′-d2]-cotinine by capillary liquid chromatography–electrospray tandem mass spectrometry

…, P Villalta, SW Ho, LB von Weymarn - … of Chromatography B, 2007 - Elsevier
A selective and sensitive LC/MS/MS assay was developed for the quantification of d 2 -nicotine
and d 2 -cotinine in plasma of current and past smokers administered d 2 -nicotine. After …

Effects of 8-methoxypsoralen on cytochrome P450 2A13

LB Von Weymarn, QY Zhang, X Ding… - …, 2005 - academic.oup.com
Cytochrome P450 2A13 efficiently catalyzes the bioactivation of several tobacco-specific
nitrosamines in vitro . This efficient bioactivation together with the selective expression of P450 …

Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption

…, M Martinez, LB Von Weymarn… - Pharmacogenetics …, 2013 - journals.lww.com
Background Flavin-containing monooxygenases (FMO) catalyze the metabolism of nucleophilic
heteroatom-containing drugs and xenobiotics, including nicotine. Rare mutations in …

UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption

JZ Berg, LB Von Weymarn, EA Thompson… - … , biomarkers & prevention, 2010 - AACR
Background: Tobacco exposure is routinely assessed by quantifying nicotine metabolites in
plasma or urine. On average, 80% of nicotine undergoes C-oxidation to cotinine. However, …