[HTML][HTML] Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
LK Brents, EE Reichard, SM Zimmerman, JH Moran… - PloS one, 2011 - journals.plos.org
Background K2 products are synthetic cannabinoid-laced, marijuana-like drugs of abuse,
use of which is often associated with clinical symptoms atypical of marijuana use, including …
use of which is often associated with clinical symptoms atypical of marijuana use, including …
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands
…, KA Seely, SM Bratton, LK Brents… - Drug metabolism and …, 2012 - ASPET
Abuse of synthetic cannabinoids (SCs), such as [1-naphthalenyl-(1-pentyl-1H-indol-3-yl]-methanone
(JWH-018) and [1-(5-fluoropentyl)-1H-indol-3-yl]-1-naphthalenyl-methanone (…
(JWH-018) and [1-(5-fluoropentyl)-1H-indol-3-yl]-1-naphthalenyl-methanone (…
Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral …
LK Brents, A Gallus-Zawada… - Biochemical …, 2012 - Elsevier
K2 and several similar purported “incense products” spiked with synthetic cannabinoids are
abused as cannabis substitutes. We hypothesized that metabolism of JWH-073, a prevalent …
abused as cannabis substitutes. We hypothesized that metabolism of JWH-073, a prevalent …
The K2/Spice phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products
LK Brents, PL Prather - Drug metabolism reviews, 2014 - Taylor & Francis
In 2008, the European Monitoring Center for Drugs and Drug Addiction (EMCDDA) detected
unregulated, psychoactive synthetic cannabinoids (SCBs) in purportedly all-natural herbal …
unregulated, psychoactive synthetic cannabinoids (SCBs) in purportedly all-natural herbal …
[HTML][HTML] Focus: sex and gender health: Marijuana, the Endocannabinoid System and the female reproductive system
LK Brents - The Yale journal of biology and medicine, 2016 - ncbi.nlm.nih.gov
Marijuana use among women is highly prevalent, but the societal conversation on marijuana
rarely focuses on how marijuana affects female reproduction and endocrinology. This …
rarely focuses on how marijuana affects female reproduction and endocrinology. This …
AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies
KA Seely, LK Brents, LN Franks, M Rajasekaran… - …, 2012 - Elsevier
Mu-opioid and CB1-cannabinoid agonists produce analgesia; however, adverse effects
limit use of drugs in both classes. Additive or synergistic effects resulting from concurrent …
limit use of drugs in both classes. Additive or synergistic effects resulting from concurrent …
Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors
M Rajasekaran, LK Brents, LN Franks, JH Moran… - Toxicology and applied …, 2013 - Elsevier
K2 or Spice is an emerging drug of abuse that contains synthetic cannabinoids, including
JWH-018 and JWH-073. Recent reports indicate that monohydroxylated metabolites of JWH-…
JWH-018 and JWH-073. Recent reports indicate that monohydroxylated metabolites of JWH-…
Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a: ZBTB10 in breast cancer
Abstract Treatment of ErbB2-overexpressing BT474 and MDA-MB-453 breast cancer cells
with 1 to 10 μmol/L betulinic acid inhibited cell growth, induced apoptosis, downregulated …
with 1 to 10 μmol/L betulinic acid inhibited cell growth, induced apoptosis, downregulated …
Repeated administration of phytocannabinoid Δ9-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor …
…, C Gu, LN Franks, T Vasiljevik, LK Brents… - Pharmacological …, 2015 - Elsevier
These studies probed the relationship between intrinsic efficacy and tolerance/cross-tolerance
between ∆ 9 -THC and synthetic cannabinoid drugs of abuse (SCBs) by examining in vivo …
between ∆ 9 -THC and synthetic cannabinoid drugs of abuse (SCBs) by examining in vivo …
A major glucuronidated metabolite of JWH-018 is a neutral antagonist at CB1 receptors
KA Seely, LK Brents… - Chemical research in …, 2012 - ACS Publications
Recently, hydroxylated metabolites of JWH-018, a synthetic cannabinoid found in many K2/Spice
preparations, have been shown to retain affinity and activity for cannabinoid type 1 …
preparations, have been shown to retain affinity and activity for cannabinoid type 1 …