The role of radiolabeled monoclonal antibodies in cancer imaging and ADC treatment

L Martiniova, RJ Zielinski, M Lin, L DePalatis… - The Cancer …, 2022 - journals.lww.com
Antibody-drug conjugates (ADCs) are designed to deliver cytotoxic payloads to distinctive
target-expressing cancer cells. Following internalization, the ADCs are routed to different …

Brain distribution of a novel MEK inhibitor E6201: implications in the treatment of melanoma brain metastases

…, JK Laramy, JN Sarkaria, L Paradiso, L DePalatis… - Drug Metabolism and …, 2018 - ASPET
Clinically meaningful efficacy in the treatment of brain tumors, including melanoma brain
metastases (MBM), requires selection of a potent inhibitor against a suitable target, and …

Correlative whole-body FDG-PET and intraoperative gamma detection of FDG distribution in colorectal cancer

…, S Saha, G Hinkle, D Soble, J Fry, LR DePalatis… - Clinical Positron …, 2000 - Elsevier
Purpose: 18 F-Fluorodeoxyglucose-positron emission tomography (FDG-PET) is the superior
imaging modality for detection of primary and recurrent colorectal cancer compared to …

Effect of unilateral orchidectomy on plasma FSH concentration: evidence for a direct neural connection between testes and CNS

H Mizunuma, LR DePalatis, SM McCann - Neuroendocrinology, 1983 - karger.com
The effect of unilateral orchidectomy on plasma FSH, LH and LHRH content in the right and
left half of the median eminence-arcuate nucleus region was examined in adult rats. …

18F-labeled fluorodeoxyglucose positron emission tomography-guided surgery for recurrent colorectal cancer: a feasibility study

EE Zervos, DC Desai, LR DePalatis, D Soble… - Journal of Surgical …, 2001 - Elsevier
Objective. Positron emission tomography (PET) scanning is an accepted diagnostic tool for
the detection of colorectal cancer (CRC). The purpose of this study was to determine whether …

Stimulatory role of substance P on gonadotropin release in ovariectomized rats

M Arisawa, L De Palatis, R Ho, GD Snyder, WH Yu… - …, 1990 - karger.com
Substance P (SP) has been shown to be present in the hypothalamus and anterior pituitary.
To evaluate a possible physiological role of endogenous SP in the control of luteinizing …

Lysine Reduces Renal Accumulation of Radioactivity Associated with Injection of the [177Lu]α-[2-(4-Aminophenyl) ethyl]-1,4,7,10-tetraaza-cyclodecane-1,4,7,10 …

LR DePalatis, KA Frazier, RC Cheng, NJ Kotite - Cancer research, 1995 - AACR
The high uptake and prolonged renal retention of monoclonal antibody fragments that are
conjugated with radiometal chelates precludes their routine clinical use due to high …

Age-, sex-, and gonadal steroid-related changes in immunoreactive substance P in the rat anterior pituitary gland

LR DEPALATIS, O KHORRAM, SM McCANN - Endocrinology, 1985 - academic.oup.com
The interrelationship of anterior pituitary lobe (AP) immunoreactive substance P (I-SP)
concentrations with age, sex, gonadal steroids, and estrous cyclicity in rats was examined. There …

Substance P immunoreactivity in the anterior pituitary gland of the guinea pig

LR DePALATIS, RP FIORINDO, RH HO - Endocrinology, 1982 - academic.oup.com
The aim of this study was to demonstrate the presence of Substance P (SP) immunoreactive
cells within the anterior pituitary gland of the adult guinea pig. By utilizing the PAP technique …

[HTML][HTML] Current Status of Radiolabeled Monoclonal Antibodies Targeting PSMA for Imaging and Therapy

M Abusalem, L Martiniova, S Soebianto, L DePalatis… - Cancers, 2023 - mdpi.com
Simple Summary The prostate-specific membrane antigen (PSMA) protein present in most
prostate cancer cells has emerged as a promising target for the imaging and treatment of …