Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage

G Brolén, L Sivertsson, P Björquist, G Eriksson… - Journal of …, 2010 - Elsevier
Human embryonic stem cells offer a potential unlimited supply for functional hepatocytes,
since they can differentiate into hepatocyte-like cells displaying a characteristic hepatic …

Hepatic differentiation and maturation of human embryonic stem cells cultured in a perfused three-dimensional bioreactor

L Sivertsson, J Synnergren, J Jensen… - Stem cells and …, 2013 - liebertpub.com
… Magnus Ingelman-Sundberg, Louise Sivertsson, and Jane Synnergren have no conflicts
of … human in vitro systems for studies of drug induced hepatotoxicity” by Louise Sivertsson. …

CYP3A4 catalytic activity is induced in confluent Huh7 hepatoma cells

L Sivertsson, M Ek, M Darnell, I Edebert… - Drug Metabolism and …, 2010 - ASPET
Drug-induced hepatotoxicity is an important cause for disapproval, limitations of use, or
withdrawal of drugs, and there is a high need for reproducible in vitro systems that can predict …

Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model

Y Edling, LK Sivertsson, A Butura… - Toxicology in Vitro, 2009 - Elsevier
Drug-induced hepatotoxicity is a major reason for withdrawal of drugs from development as
well as from the market. A major problem predicting hepatotoxicity is the lack of suitable …

Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane X receptor activation

L Sivertsson, I Edebert, MP Palmertz… - Molecular …, 2013 - ASPET
We have previously shown that confluent growth of the human hepatoma cell line Huh7
substantially induces the CYP3A4 mRNA, protein, and activity levels. Here, the mechanisms …

Pro-inflammatory response and adverse drug reactions: mechanisms of action of ximelagatran on chemokine and cytokine activation in a monocyte in vitro model

Y Edling, L Sivertsson, TB Andersson… - Toxicology in Vitro, 2008 - Elsevier
There is a lack of suitable human in vitro systems which can predict drug hepatotoxicity that
in many cases involves inflammatory responses mediated by macrophages. In the present …

Induced CYP3A4 expression in confluent Huh7 hepatoma cells as a result of decreased cell proliferation and subsequent PXR activation

L Sivertsson, I Edebert, MP Palmertz… - Molecular …, 2012 - ASPET
We have previously shown that confluent growth of the human hepatoma cell line Huh7
substantially induces the CYP3A4 mRNA, protein and activity levels. Here, the mechanisms …

What about tomorrow: design for the unknown future in healthcare architecture

S Louise - 2021 - odr.chalmers.se
We have for a long time researched on history but at the same time we are striving towards
an unknown future. To be able to become more sustainable we need to plan for the future in …

[BOOK][B] Novel Human in Vitro Systems for Studies of Drug Inducted Hepatotoxicity

L Sivertsson - 2012 - search.proquest.com
Drug-induced liver injury (DILI) is a major human health concern, estimated to account for
about half of all cases of acute liver failure in the general population. DILI also represents a …

[CITATION][C] Confluent Growth of Huh7 Human Hepatoma Cells Induces Transcriptional Activation of the CYP3A4 Gene

L Sivertsson, M Ek, M Darnell… - DRUG …, 2010 - … & FRANCIS INC 325 CHESTNUT ST …