User profiles for Lukas Cerveny
 | Lukas CervenyAssoc. Prof., Faculty of Pharmacy in Hradec Kralove, Charles University in Prague Verified email at faf.cuni.cz Cited by 1998 |
Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways
L Cerveny, L Svecova, E Anzenbacherova… - Drug Metabolism and …, 2007 - ASPET
In our study, we tested the hypothesis whether valproic acid (VPA) in therapeutic concentrations
has potential to affect expression of CYP3A4 and MDR1 via constitutive androstane …
has potential to affect expression of CYP3A4 and MDR1 via constitutive androstane …
Tetratricopeptide repeat motifs in the world of bacterial pathogens: role in virulence mechanisms
L Cerveny, A Straskova, V Dankova… - Infection and …, 2013 - Am Soc Microbiol
The tetratricopeptide repeat (TPR) structural motif is known to occur in a wide variety of
proteins present in prokaryotic and eukaryotic organisms. The TPR motif represents an elegant …
proteins present in prokaryotic and eukaryotic organisms. The TPR motif represents an elegant …
Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure
Pharmacotherapy during pregnancy is often inevitable for medical treatment of the mother,
the fetus or both. The knowledge of drug transport across placenta is, therefore, an important …
the fetus or both. The knowledge of drug transport across placenta is, therefore, an important …
Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta
Objective and design: Tenofovir (TFV) is used in pregnant women as a part of combination
antiretroviral treatment to prevent mother-to-child transmission of HIV infection. We aimed to …
antiretroviral treatment to prevent mother-to-child transmission of HIV infection. We aimed to …
Organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter in the placenta and fetal tissues: expression profile …
…, E Dolezelova, Z Neumanova, L Cerveny… - Biology of …, 2013 - academic.oup.com
In our previous study, we described synchronized activity of organic cation transporter 3 (OCT3/SLC22A3)
and multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter in the …
and multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter in the …
Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics
Mammal multidrug and toxin extrusion protein 1 (MATE 1) encoded by SLC47A1 gene was
described in 2005 as an efflux transporter that mediates proton-coupled organic cation …
described in 2005 as an efflux transporter that mediates proton-coupled organic cation …
Serotonin homeostasis in the materno‐foetal interface at term: Role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO‐A) in …
…, P Kastner, A Matthios, L Cerveny… - Acta …, 2020 - Wiley Online Library
Aim Serotonin is crucial for proper foetal development, and the placenta has been described
as a ‘donor’ of serotonin for the embryo/foetus. However, in later stages of gestation the …
as a ‘donor’ of serotonin for the embryo/foetus. However, in later stages of gestation the …
[HTML][HTML] Dynamics of tryptophan metabolic pathways in human placenta and placental-derived cells: effect of gestation age and trophoblast differentiation
…, P Kastner, J Zaugg, L Cerveny… - Frontiers in cell and …, 2020 - frontiersin.org
L-Tryptophan is an essential amino acid and a precursor of several physiologically active
metabolites. In the placenta, the serotonin and kynurenine metabolic pathways of tryptophan …
metabolites. In the placenta, the serotonin and kynurenine metabolic pathways of tryptophan …
[HTML][HTML] Effect of selected antidepressants on placental homeostasis of serotonin: maternal and fetal perspectives
H Horackova, R Karahoda, L Cerveny, V Vachalova… - Pharmaceutics, 2021 - mdpi.com
Depression is a prevalent condition affecting up to 20% of pregnant women. Hence, more
than 10% are prescribed antidepressant drugs, mainly serotonin reuptake inhibitors (SSRIs) …
than 10% are prescribed antidepressant drugs, mainly serotonin reuptake inhibitors (SSRIs) …
[HTML][HTML] HIV in pregnancy: Mother-to-child transmission, pharmacotherapy, and toxicity
An estimated 1.3 million pregnant women were living with HIV in 2018. HIV infection is
associated with adverse pregnancy outcomes and all HIV-positive pregnant women, regardless …
associated with adverse pregnancy outcomes and all HIV-positive pregnant women, regardless …