[HTML][HTML] The drug-resistance mechanisms of five platinum-based antitumor agents
…, L Chen, H Wang, J Liu, S Zeng, L Yu - Frontiers in …, 2020 - frontiersin.org
Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin,
and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or …
and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or …
The role of non-coding RNAs in ABC transporters regulation and their clinical implications of multidrug resistance in cancer
Y Wang, Y Wang, Z Qin, S Cai, L Yu… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction Multi-drug resistance (MDR) is a hindrance toward the successful treatment of
cancers. The primary mechanism that gives rise to acquired chemoresistance is the …
cancers. The primary mechanism that gives rise to acquired chemoresistance is the …
[HTML][HTML] Research and development of drug delivery systems based on drug transporter and nano-formulation
…, L Chen, S Ye, Y Kang, J Liu, S Zeng, L Yu - Asian journal of …, 2020 - Elsevier
In recent years, the continuous occurrence of multi-drug resistance in the clinic has made
people pay more attention to the transporter. Changes in the expression and activity of …
people pay more attention to the transporter. Changes in the expression and activity of …
VARIDT 2.0: structural variability of drug transporter
…, W Qiu, X Li, X Liu, W Xin, C Wang, L Yu… - Nucleic Acids …, 2022 - academic.oup.com
The structural variability data of drug transporter (DT) are key for research on precision medicine
and rational drug use. However, these valuable data are not sufficiently covered by the …
and rational drug use. However, these valuable data are not sufficiently covered by the …
VARIDT 1.0: variability of drug transporter database
…, N Chen, X Jin, J Xue, S Zeng, L Yu… - Nucleic acids …, 2020 - academic.oup.com
The absorption, distribution and excretion of drugs are largely determined by their transporters
(DTs), the variability of which has thus attracted considerable attention. There are three …
(DTs), the variability of which has thus attracted considerable attention. There are three …
INTEDE: interactome of drug-metabolizing enzymes
…, Y Luo, J Fu, X He, J Gao, S Zeng, L Yu… - Nucleic Acids …, 2021 - academic.oup.com
Drug-metabolizing enzymes (DMEs) are critical determinant of drug safety and efficacy, and
the interactome of DMEs has attracted extensive attention. There are 3 major interaction …
the interactome of DMEs has attracted extensive attention. There are 3 major interaction …
Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin
Y Liu, X Zheng, Q Yu, H Wang, F Tan, Q Zhu… - Science translational …, 2016 - science.org
Renal cell carcinoma (RCC) is known for its multidrug resistance. Using data obtained from
the cancer transcriptome database Oncomine and the proteome database The Human …
the cancer transcriptome database Oncomine and the proteome database The Human …
Identification of novel pregnane X receptor activators from traditional Chinese medicines
C Yu, X Chai, L Yu, S Chen, S Zeng - Journal of ethnopharmacology, 2011 - Elsevier
… Author links open overlay panel Chunna Yu a b 1 , Xiaojuan Chai a 1 , Lushan Yu a , Shuqing
Chen a , … Zeng) and National Natural Science Foundation of China (81001475) (CN Yu). …
Chen a , … Zeng) and National Natural Science Foundation of China (81001475) (CN Yu). …
LncRNA regulation: New frontiers in epigenetic solutions to drug chemoresistance
…, W Sun, Z Qin, S Guo, Y Kang, S Zeng, L Yu - Biochemical …, 2021 - Elsevier
Long-noncoding RNAs (lncRNAs) have been shown to participate in sensitizing or de-sensitizing
cancer cells to chemical drugs during cancer therapeutics. Notably, a plethora of …
cancer cells to chemical drugs during cancer therapeutics. Notably, a plethora of …
VARIDT 3.0: the phenotypic and regulatory variability of drug transporter
…, F Li, H Zhang, J Xue, H Ma, Q Zhao, L Yu… - Nucleic Acids …, 2024 - academic.oup.com
The phenotypic and regulatory variability of drug transporter (DT) are vital for the understanding
of drug responses, drug-drug interactions, multidrug resistances, and so on. The ADME …
of drug responses, drug-drug interactions, multidrug resistances, and so on. The ADME …