Acetaminophen (APAP)-induced liver toxicity occurs with formation of APAP-protein adducts.
These adducts are formed by hepatic metabolism of APAP to N-acetyl-p-benzoquinone …

ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer and
hypothesized to be tumor suppressive. In some hepatocellular carcinoma patients, ARID1A was …

Background & Aims A rapid and reliable point-of-care assay to detect acetaminophen
protein adducts in the serum of patients with acute liver injury could improve diagnosis and …

In an effort to explain the increased incidence of serum sickness-like reactions (SSLR) in
patients receiving cefaclor, we used an in vitro murine microsomal system as a surrogate for in …

In overdose acetaminophen (APAP) is hepatotoxic. Toxicity occurs by metabolism to N-acetyl-p-benzoquinone
imine, which depletes GSH and covalently binds to proteins followed by …

Aim: Long-chain acylcarnitines have been postulated to be sensitive biomarkers of
acetaminophen (APAP)-induced hepatotoxicity in mouse models. In the following study, the …

A simple, rapid method of determining the ibuprofen concentration in small volumes of human
plasma (50 μl) by HPLC was developed. The sample was prepared for injection using a …

MicroRNAs (miRNAs) that regulate the cytochrome P-450 isoforms involved in acetaminophen
(APAP) toxicity were examined in HepaRG cells treated with APAP (20 mM). In-vitro …

(Cancer Cell 32, 204–220; August 14, 2017) During the course of revising the manuscript,
the authors inadvertently did not include the reference to a paper by Royer-Bertrand et al. in …

3-Nitrotyrosine (3NT) in liver proteins of mice treated with hepatotoxic doses of acetaminophen
(APAP) has been postulated to be causative in toxicity. Nitration is by a reactive nitrogen …