Introduction: P-glycoprotein (P-gp)/ABCB1 and breast cancer resistance protein (BCRP)/ABCG2
are highly expressed in the placenta and fetus throughout gestation and can modulate …

The metabolism of testosterone to 6β-hydroxytestosterone (6β-OH-T) is a commonly used
assay to evaluate human CYP3A enzyme activities. However, previous reports have indicated …

Drug development for idiopathic pulmonary fibrosis (IPF) has been challenging due to poorly
understood disease etiology, unpredictable disease progression, highly heterogeneous …

Vitamin D 3 is an important prohormone critical for maintaining calcium and phosphate
homeostasis in the body and regulating drug-metabolizing enzymes and transporters. 25-…

Hydralazine, an antihypertensive agent used during pregnancy, undergoes N‐acetylation
primarily via N‐acetyltransferase 2 (NAT2) to form 3‐methyl‐1,2,4‐triazolo[3,4‐a]phthalazine (…

Pregnancy is associated with metabolic changes to accommodate the mother and her growing
fetus. The microbiome has been shown to modulate host metabolism of endogenous and …

Norbuprenorphine (NBUP) is the major active metabolite of buprenorphine (BUP) that is
commonly used to treat opiate addiction during pregnancy; it possesses 25% of BUP’s …

The microbiome and pregnancy are known to alter drug disposition, yet the interplay of the
two physiologic factors on the expression and/or activity of drug metabolizing enzymes and …

Marijuana is one of the most abused drugs among pregnant women leading to maternal and
fetal abnormalities. Cannabinoids are the active ingredients of marijuana, which interact …

… Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao* … Han et al. …
Wrote or contributed to the writing of the manuscript: Han, Gao, Zhang, Wang, Mao. …