A longitudinal large-scale objective sleep data analysis revealed a seasonal sleep variation in the Japanese population

M Hashizaki, H Nakajima, T Shiga… - Chronobiology …, 2018 - Taylor & Francis
… equivalent sleep judgment potency as actigraphy in 2012 (Hashizaki et al. Citation2014), and
… in sleep time between weekends and weekdays (Hashizaki et al. Citation2015). The aim of …

[HTML][HTML] Monitoring of weekly sleep pattern variations at home with a contactless biomotion sensor

M Hashizaki, H Nakajima, K Kume - Sensors, 2015 - mdpi.com
… , Hiroshi Nakajima and Kazuhiko Kume conceived the study design, Masanori Hashizaki
gathered and analyzed the data, and Masanori Hashizaki, Hiroshi Nakajima and Kazuhiko …

[HTML][HTML] B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction

…, S Nirasawa, T Sato, T Yamaguchi, M Hoshizaki… - Nature …, 2020 - nature.com
Angiotensin-converting enzyme 2 (ACE2) is critically involved in cardiovascular physiology
and pathology, and is currently clinically evaluated to treat acute lung failure. Here we show …

[HTML][HTML] ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury

T Yamaguchi, M Hoshizaki, T Minato… - Nature …, 2021 - nature.com
Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-2, and
recombinant soluble ACE2 protein inhibits SARS-CoV-2 infection as a decoy. ACE2 is a …

m6A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis

…, S Motoyama, T Yamaguchi, M Hoshizaki… - Genes to …, 2020 - Wiley Online Library
… When we searched for consensus sequence of m 6 A modification in CDKN1A mRNA, 14
putative m 6 A sites were found in the 3' UTR (not shown). We further performed RNA …

[HTML][HTML] Anxiolytic Effects of Acanthopanax senticosus HARMS Occur via Regulation of Autonomic Function and Activate Hippocampal BDNF–TrkB Signaling

…, H Oikawa, H Takekoshi, M Hoshizaki, M Ogata… - Molecules, 2018 - mdpi.com
Mental stress, such as anxiety and conflict, causes physiological changes, such as changes
in autonomic nervous activity and gastric ulcers. In addition, stress induces glucocorticoids …

Accuracy validation of sleep measurements by a contactless biomotion sensor on subjects with suspected sleep apnea

M Hashizaki, H Nakajima, M Tsutsumi, T Shiga… - Sleep and Biological …, 2014 - Springer
Due to the busy lifestyles of people in developed countries, insufficient sleep has emerged
as a central health issue in the general population. Objective home sleep monitoring is …

Identification of Galectin-7 as a crucial metastatic enhancer of squamous cell carcinoma associated with immunosuppression

J An, Y Nagaki, S Motoyama, Y Kuze, M Hoshizaki… - Oncogene, 2022 - nature.com
Metastasis predicts poor prognosis in cancer patients. It has been recognized that specific
tumor microenvironment defines cancer cell metastasis, whereas the underlying mechanisms …

Metabolism of 3-tert-butyl-4-hydroxyanisole by horseradish peroxidase and hydrogen peroxide.

K Tajima, M Hashizaki, K Yamamoto… - Drug metabolism and …, 1992 - ASPET
3-Tert-butyl-4-hydroxyanisole (3-BHA) was metabolized in the presence of horseradish
peroxidase and hydrogen peroxide to 2-tert-butyl-p-benzoquinone (TBQ), 2,3-epoxy-5-tert-butyl-1…

Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection

S Fujiwara, M Hoshizaki, Y Ichida, D Lex… - Nature …, 2019 - nature.com
Crosstalk between the autonomic nervous system and the immune system by means of the
sympathetic and parasympathetic pathways is a critical process in host defence. Activation of …