In untreated phenylketonuria (PKU), deficiency of phenylalanine hydroxylase (PAH) results
in elevated blood phenylalanine (Phe) concentrations and severe mental retardation. …

Structure activity relationships (SAR), three-dimensional structure activity relationships (3D-QSAR),
and pharmacophores represent useful tools in understanding cytochrome P450 (CYP…

Voltage‐gated sodium channels are key to the initiation and propagation of action potentials
in electrically excitable cells. Molecular characterization has shown there to be nine …

Flavonoids are a group of naturally occurring antioxidants, which over the past years have
gained tremendous interest because of their possible therapeutic applicability. The …

We determined whether T‐DNA molecules introduced into plant cells using Agrobacterium
are suitable substrates for homologous recombination. For the detection of such …

Block of human ether-a-go-go related gene (HERG) K + channels by a variety of medications
has been linked to acquired long QT syndrome, a disorder of cardiac repolarization that …

The ability to cross the blood brain barrier (BBB), sometimes expressed as BBB+ and BBB−,
is a very important property in drug design. Several computational methods have been …

Many 3D ligand-based and structure-based computational approaches have been used to
predict, and thus help explain, the metabolism catalyzed by the enzymes of the cytochrome …

… For a recent review of these models, see de Groot and Vermeulen. CYP102 is considered
to provide the most useful structural information for homology studies on eukaryotic P450s, …

Notwithstanding the success of the traditional dietary phenylalanine restriction treatment in
phenylketonuria (PKU), the use of large neutral amino acid (LNAA) supplementation rather …