Taxanes belong to a new group of antineoplastic agents with a novel mechanism of action
for a cytotoxic drug. They promote microtubule assembly and stabilize the microtubules. …

Background: An increasing amount of reports are being published suggesting a relationship
between the use of bisphosphonates (BPs) and the development of osteonecrosis of the …

Osteonecrosis of the jaw is a distinct entity of uncertain origin that is increasingly being observed
in patients treated with potent aminobisphosphonates, although the etiology is probably …

Purpose: To investigate the pharmacokinetics and pharmacodynamics of paclitaxel in a
randomized comparative study with four different treatment arms in patients with platinum-…

The non-linear plasma pharmacokinetics of paclitaxel in patients has been well established,
however, the exact underlying mechanism remains to be elucidated. We have previously …

… Huizing, MD, PhD, Departments of Medical Oncology and Pharmacy, Louwesweg 6,
1066 EC Amsterdam, the Netherlands. … HUIZING ET AL … HUIZING ET AL …

Background Overall survival (OS) and outcome of cancer patients with bisphosphonate-associated
osteonecrosis of the jaw (ONJ) using conservative treatment (chlorhexidine 0.12% …

Background New therapeutic options are needed for patients with heavily pretreated breast
cancer. Etirinotecan pegol is a long-acting topoisomerase-I inhibitor designed to provide …

Purpose The purpose of this study was to assess the necessity of post-marketing safety
monitoring focused on osteonecrosis of the jaw (ONJ) in patients with bone metastatic cancer …

Background Breast cancer has, due to its high incidence, the highest mortality of cancer in
women. The most common molecular type of breast cancer is the luminal subtype, which …