BACKGROUND & AIMS: Altered gastrointestinal motility is associated with significant
morbidity and health care costs. Toll-like receptors (TLR) regulate intestinal homeostasis. We …

Diabetes can result in loss of enteric neurons and subsequent gastrointestinal complications.
The mechanism of enteric neuronal loss in diabetes is not known. We examined the effects …

Gastrointestinal (GI) dysfunction is the most common non-motor symptom of Parkinson's
disease (PD). Symptoms of GI dysmotility include early satiety and nausea from delayed gastric …

Background Gastrointestinal dysfunction is very common in diabetic patients. We assessed
the changes in the colonic enteric nervous system using colectomy specimens and intestinal …

Increasing evidence supports the view that intestinal farnesoid X receptor (FXR) is involved
in glucose tolerance and that FXR signaling can be profoundly impacted by the gut …

Background & Aims High-fat diet (HFD) feeding is associated with gastrointestinal motility
disorders. We recently reported delayed colonic motility in mice fed a HFD for 11 weeks. In this …

Background & Aims A high-fat diet (HFD) can cause serious health problems, including
alteration of gastrointestinal transit, the exact mechanism of which is not clear. Several …

Intestinal bacteria play an important role in bile acid metabolism and in the regulation of
multiple host metabolic pathways (eg, lipid and glucose homeostasis) through modulation of …

Background & Aims: The isolation and culture of primary enteric neurons is a difficult process
and yields a small number of neurons. We developed fetal and postnatal enteric neuronal …

Glial cell line-derived neurotrophic factor (GDNF)/Ret signaling is required for enteric neural
crest survival, proliferation, migration and process extension, but signaling pathways that …