User profiles for Manthena V Varma

Manthena V. Varma

Pharmacokinetics, dynamics and metabolism
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Cited by 7722

P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement

MVS Varma, Y Ashokraj, CS Dey… - Pharmacological …, 2003 - Elsevier
Drug efflux pumps like P-glycoprotein (P-gp) and multidrug resistance (MDR) proteins were
recognized to posses functional role in determining the pharmacokinetics of drugs …

Enhanced oral paclitaxel absorption with vitamin E-TPGS: effect on solubility and permeability in vitro, in situ and in vivo

MVS Varma, R Panchagnula - European journal of pharmaceutical …, 2005 - Elsevier
Solubility and permeability being important determinants of oral drug absorption, this study
was aimed to investigate the effect of d-α-tocopheryl polyethylene glycol 1000 succinate (…

Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination

MVS Varma, RS Obach, C Rotter… - Journal of medicinal …, 2010 - ACS Publications
Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall
elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a database …

Development of a new permeability assay using low‐efflux MDCKII cells

…, EL Reyner, C Lee, B Feng, C Rotter, MV Varma… - Journal of …, 2011 - Elsevier
Permeability is an important property of drug candidates. The Madin–Darby canine kidney
cell line (MDCK) permeability assay is widely used and the primary concern of using MDCK …

Predicting clearance mechanism in drug discovery: extended clearance classification system (ECCS)

MV Varma, SJ Steyn, C Allerton, AF El-Kattan - Pharmaceutical research, 2015 - Springer
Early prediction of clearance mechanisms allows for the rapid progression of drug discovery
and development programs, and facilitates risk assessment of the pharmacokinetic …

Factors affecting mechanism and kinetics of drug release from matrix-based oral controlled drug delivery systems

MVS Varma, AM Kaushal, A Garg, S Garg - American Journal of drug …, 2004 - Springer
Matrix technologies have often proven popular among the oral controlled drug delivery
technologies because of their simplicity, ease in manufacturing, high level of reproducibility, …

Physicochemical determinants of human renal clearance

MVS Varma, B Feng, RS Obach… - Journal of medicinal …, 2009 - ACS Publications
Kidney plays an important role in the elimination of drugs, especially with low or negligible
hepatic clearance. An analysis of the interrelation of physicochemical properties and the …

Functional role of P-glycoprotein in limiting intestinal absorption of drugs: contribution of passive permeability to P-glycoprotein mediated efflux transport

MVS Varma, K Sateesh… - Molecular …, 2005 - ACS Publications
The aim of the present study is to evaluate the quantitative contribution of passive permeability
to P-glycoprotein-mediated (P-gp-mediated) efflux and the functional activity of P-gp in …

pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery

MV Varma, I Gardner, SJ Steyn, P Nkansah… - Molecular …, 2012 - ACS Publications
The Biopharmaceutics Classification System (BCS) is a scientific framework that provides a
basis for predicting the oral absorption of drugs. These concepts have been extended in the …

Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions

MVS Varma, Y Lai, B Feng, J Litchfield… - Pharmaceutical …, 2012 - Springer
Purpose To develop physiologically based pharmacokinetic (PBPK) model to predict the
pharmacokinetics and drug-drug interactions (DDI) of pravastatin, using the in vitro transport …