User profiles for Manthena V Varma
Manthena V. VarmaPharmacokinetics, dynamics and metabolism Verified email at pfizer.com Cited by 7722 |
P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement
MVS Varma, Y Ashokraj, CS Dey… - Pharmacological …, 2003 - Elsevier
Drug efflux pumps like P-glycoprotein (P-gp) and multidrug resistance (MDR) proteins were
recognized to posses functional role in determining the pharmacokinetics of drugs …
recognized to posses functional role in determining the pharmacokinetics of drugs …
Enhanced oral paclitaxel absorption with vitamin E-TPGS: effect on solubility and permeability in vitro, in situ and in vivo
MVS Varma, R Panchagnula - European journal of pharmaceutical …, 2005 - Elsevier
Solubility and permeability being important determinants of oral drug absorption, this study
was aimed to investigate the effect of d-α-tocopheryl polyethylene glycol 1000 succinate (…
was aimed to investigate the effect of d-α-tocopheryl polyethylene glycol 1000 succinate (…
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination
MVS Varma, RS Obach, C Rotter… - Journal of medicinal …, 2010 - ACS Publications
Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall
elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a database …
elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a database …
Development of a new permeability assay using low‐efflux MDCKII cells
Permeability is an important property of drug candidates. The Madin–Darby canine kidney
cell line (MDCK) permeability assay is widely used and the primary concern of using MDCK …
cell line (MDCK) permeability assay is widely used and the primary concern of using MDCK …
Predicting clearance mechanism in drug discovery: extended clearance classification system (ECCS)
MV Varma, SJ Steyn, C Allerton, AF El-Kattan - Pharmaceutical research, 2015 - Springer
Early prediction of clearance mechanisms allows for the rapid progression of drug discovery
and development programs, and facilitates risk assessment of the pharmacokinetic …
and development programs, and facilitates risk assessment of the pharmacokinetic …
Factors affecting mechanism and kinetics of drug release from matrix-based oral controlled drug delivery systems
Matrix technologies have often proven popular among the oral controlled drug delivery
technologies because of their simplicity, ease in manufacturing, high level of reproducibility, …
technologies because of their simplicity, ease in manufacturing, high level of reproducibility, …
Physicochemical determinants of human renal clearance
MVS Varma, B Feng, RS Obach… - Journal of medicinal …, 2009 - ACS Publications
Kidney plays an important role in the elimination of drugs, especially with low or negligible
hepatic clearance. An analysis of the interrelation of physicochemical properties and the …
hepatic clearance. An analysis of the interrelation of physicochemical properties and the …
Functional role of P-glycoprotein in limiting intestinal absorption of drugs: contribution of passive permeability to P-glycoprotein mediated efflux transport
The aim of the present study is to evaluate the quantitative contribution of passive permeability
to P-glycoprotein-mediated (P-gp-mediated) efflux and the functional activity of P-gp in …
to P-glycoprotein-mediated (P-gp-mediated) efflux and the functional activity of P-gp in …
pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery
MV Varma, I Gardner, SJ Steyn, P Nkansah… - Molecular …, 2012 - ACS Publications
The Biopharmaceutics Classification System (BCS) is a scientific framework that provides a
basis for predicting the oral absorption of drugs. These concepts have been extended in the …
basis for predicting the oral absorption of drugs. These concepts have been extended in the …
Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions
Purpose To develop physiologically based pharmacokinetic (PBPK) model to predict the
pharmacokinetics and drug-drug interactions (DDI) of pravastatin, using the in vitro transport …
pharmacokinetics and drug-drug interactions (DDI) of pravastatin, using the in vitro transport …