The present study was designed to define an experimental model of hepatocellular steatosis
with a fat overaccumulation profile in which the metabolic and cytotoxic/apoptotic effects …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …

This review brings you up-to-date with the hepatocyte research on: 1) in vitro–in vivo
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross-talk …

AIM: To investigate and compare the hepatogenic transdifferentiation of adipose tissue-derived
stem cells (ADSC) and bone marrow-derived mesenchymal stem cells (BMSC) in vitro. …

Hepatoma cell lines are frequently used as in vitro alternatives to primary human hepatocytes.
Cell lines are characterized by their unlimited life span, stable phenotype, high availability…

Lung is a target organ for the toxicity of inhalated compounds. The respiratory tract is frequently
exposed to elevated concentrations of these compounds and become the primary target …

Cytotoxicity assays were among the first in vitro bioassay methods used to predict toxicity of
substances to various tissues. In vitro cytotoxicity testing provides a crucial means for safety …

Human hepatocytes in primary culture were used as a model system to investigate the
mechanism (s) involved in the induction of the acute-phase response in human liver. Hepatocytes …

The pharmaceutical industry is committed to marketing safer drugs with fewer side effects,
predictable pharmacokinetic properties and quantifiable drug–drug interactions. Drug …

The aim of this study was to re-examine the human hepatic metabolism of diclofenac, with
special focus on the generation of minor hydroxylated metabolites implicated in the …