Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no
effective treatment, yet the molecular basis of hepatocarcinogenesis remains largely unknown…

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease that regulates low
density lipoprotein receptor (LDLR) protein levels. The mechanisms of this action, however, …

The carboxylesterases (CESs) are a family of serine hydrolases that hydrolyze compounds
containing an ester, amide, or thioester. In humans, two dominant forms, CES1 and CES2, …

INTRODUCTION: The effects of buffer and substrate solvent conditions on in vitro activity of
carboxylesterases (CE) have not been previously described. Therefore, it is unknown if the …

We have developed a cosmid and plasmid system to generate mutant strains of murine
cytomegalovirus (MCMV). The system is based on a series of seven overlapping cosmid clones …

The last step in sphingolipid biosynthesis is the conversion of ceramide (Cer) to sphingomyelin
(SM), which is catalyzed by sphingomyelin synthase (SMS). Two isoforms of SMS have …

ATP-binding cassette transporter A-1 (ABCA1) mediates the transfer of cellular cholesterol
to lipid-poor apolipoproteins. Liver X receptors (LXRs) are regulators of cholesterol …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the most recently identified member
of the proprotein convertase family. Genetic and cell biology studies have suggested a …

Background Past research in population health trends has shown that injuries form a
substantial burden of population health loss. Regular updates to injury burden assessments are …

Background Health-care needs change throughout the life course. It is thus crucial to assess
whether health systems provide access to quality health care for all ages. Drawing from the …