Cloning and functional expression of GABAB receptors from Drosophila

M Mezler, T Müller, K Raming - European Journal of …, 2001 - Wiley Online Library
The neurotransmitter GABA (γ‐aminobutyric acid) functions as the major inhibitory neurotransmitter
in the central nervous system of vertebrates and invertebrates. In vertebrates GABA …

Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades

…, M Schmidt, AH Meyer, L Unger, GJ Marek, M Mezler - …, 2012 - Elsevier
Dopamine, serotonin and glutamate play a role in the pathophysiology of schizophrenia. In
the brain a functional crosstalk between the serotonin receptor 5-HT 2A and the metabotropic …

Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats

…, KU Drescher, M van Gaalen, AL Relo, M Mezler… - … of Pharmacology and …, 2010 - ASPET
Orthosteric group II metabotropic glutamate receptor (mGluR) agonists are regarded as novel,
effective medications for all major symptom domains of schizophrenia, including cognitive …

The two faces of the pharmacological interaction of mGlu2 and 5-HT2A–relevance of receptor heterocomplexes and interaction through functional brain pathways

HK Delille, M Mezler, GJ Marek - Neuropharmacology, 2013 - Elsevier
Important functional interactions between the metabotropic glutamate 2 (mGlu 2 ) and 5-hydroxytryptamine
2A (5-HT 2A ) neurotransmitter receptors have been established based on …

Awake rat pharmacological magnetic resonance imaging as a translational pharmacodynamic biomarker: metabotropic glutamate 2/3 agonist modulation of ketamine …

…, GJ Marek, SJ Baker, M Zhang, M Mezler… - … of Pharmacology and …, 2011 - ASPET
Neuroimaging techniques have been exploited to characterize the effect of N-methyl-d-aspartate
(NMDA) receptor antagonists on brain activation in humans and animals. However, …

[HTML][HTML] Novel Developments to Enable Treatment of Cns Diseases with Targeted Drug Delivery

AH Meyer, TM Feldsien, M Mezler, C Untucht… - Pharmaceutics, 2023 - mdpi.com
The blood-brain barrier (BBB) is a major hurdle for the development of systemically delivered
drugs against diseases of the central nervous system (CNS). Because of this barrier there …

Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression

…, IA Sukhotina, K Wicke, M Mezler… - European journal of …, 2008 - Elsevier
There is a growing body of evidence indicating that stimulation of metabotropic glutamate type
II receptors (mGlu 2/3 ) reduces anxiety in laboratory animals and humans. Surprisingly, it …

Inhibitors of GlyT1 affect glycine transport via discrete binding sites

M Mezler, W Hornberger, R Mueller, M Schmidt… - Molecular …, 2008 - ASPET
In the forebrain, synaptic glycine concentrations are regulated through the glycine transporter
GlyT1. Because glycine is a coagonist of the N-methyl-d-aspartate (NMDA) receptor (…

Characteristic features and ligand specificity of the two olfactory receptor classes from Xenopus laevis

M Mezler, J Fleischer, H Breer - Journal of Experimental …, 2001 - journals.biologists.com
Amphibia have two classes of olfactory receptors (ORs), class I (fish-like receptors) and class
II (mammalian-like receptors). These two receptor classes correspond to the two classes …

[PDF][PDF] LY-2140023, a prodrug of the group II metabotropic glutamate receptor agonist LY-404039 for the potential treatment of schizophrenia

M Mezler, H Geneste, L Gault… - Curr Opin Investig Drugs, 2010 - researchgate.net
Schizophrenia is a chronic mental disorder that causes a range of psychological symptoms
including hallucinations, delusions and abnormal cognitive functioning [1102392]. New …