Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays

…, B Booth, AJ DeStefano, MJ Rose, J Sailstad… - Pharmaceutical …, 2007 - Springer
Abstract The Third AAPS/FDA Bioanalytical Workshop, entitled “Quantitative Bioanalytical
Methods Validation and Implementation: Best Practices for Chromatographic and Ligand …

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

…, JP Kesslak, L Ni, MH Norman, G Palluconi, MJ Rose… - Pain, 2008 - journals.lww.com
The vanilloid receptor TRPV1 has been identified as a molecular target for the treatment of
pain associated with inflammatory diseases and cancer. Hence, TRPV1 antagonists have …

Workshop/conference report—quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays

…, B Booth, AJ DeStefano, MJ Rose, J Sailstad… - The AAPS Journal, 2007 - Springer
Conclusion For quantitative bioanalytical method validation procedure and requirements,
there was a relatively good agreement between chromatographic assays and ligand-binding …

Platelets are essential for leukocyte recruitment in allergic inflammation

…, R Lever, Y Riffo-Vasquez, S Ciferri, MJ Rose… - Journal of allergy and …, 2003 - Elsevier
Background: The role of platelets in inflammation is recognized but poorly characterized, and
little is known of their interaction with leukocytes. However, platelet-leukocyte interactions …

Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS

H Li, MJ Rose, L Tran, J Zhang, LP Miranda… - … of pharmacological and …, 2009 - Elsevier
INTRODUCTION: Hepcidin, a 25-amino acid peptide hormone, plays a crucial regulatory role
in iron metabolism. Elevated hepcidin has been observed in response to inflammation and …

In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: correlation with CYP2C9 …

…, Q Mei, P Sandhu, EJ Woolf, MJ Rose… - Pharmacogenetics …, 2001 - journals.lww.com
In-vitro studies were conducted to assess the impact of CYP2C9 genotype on the metabolism
(methyl hydroxylation) and pharmacokinetics of celecoxib, a novel cyclooxygenase-2 …

Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline

…, LF Epstein, MR Lee, MJ Rose… - Journal of medicinal …, 2009 - ACS Publications
The discovery and optimization of a novel series of aminoisoquinolines as potent, selective,
and efficacious inhibitors of the mutant B-Raf pathway is presented. The N-linked …

Single‐and multiple‐dose pharmacokinetics of etoricoxib, a selective inhibitor of cyclooxygenase‐2, in man

…, AG Porras, CZ Matthews, MJ Rose… - The Journal of …, 2003 - Wiley Online Library
The single‐ and multiple‐dose pharmacokinetics of etoricoxib, a selective inhibitor of
cyclooxygenase‐2, were examined in two clinical studies. Single‐dose pharmacokinetics—…

Pharmacokinetics of anti-hepcidin monoclonal antibody Ab 12B9m and hepcidin in cynomolgus monkeys

JJ Xiao, W Krzyzanski, YM Wang, H Li, MJ Rose, M Ma… - The AAPS journal, 2010 - Springer
Hepcidin is a key regulator responsible for systemic iron homeostasis. A semi-mechanistic
PK model for hepcidin and a fully human anti-hepcidin monoclonal antibody (Ab 12B9m) was …

Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity

…, CV Gegg, A Patel, J Aral, J Long, J Zhang… - Journal of medicinal …, 2008 - ACS Publications
A series of conformationally constrained derivatives of glucagon-like peptide-1 (GLP-1) were
designed and evaluated. By use of [Gly 8 ]GLP-1(7–37)-NH 2 (2) peptide as a starting point…