User profiles for Mark Kemp

Mark Kemp

Senior Staff Scientist at SLAC National Accelerator Laboratory
Verified email at slac.stanford.edu
Cited by 768

[HTML][HTML] A high Q piezoelectric resonator as a portable VLF transmitter

MA Kemp, M Franzi, A Haase, E Jongewaard… - Nature …, 2019 - nature.com
Very low frequency communication systems (3 kHz–30 kHz) enable applications not feasible
at higher frequencies. However, the highest radiation efficiency antennas require size at …

A novel selective and orally bioavailable Nav1.8 channel blocker, PF‐01247324, attenuates nociception and sensory neuron excitability

…, P Anand, PJ Bungay, M Kemp… - British journal of …, 2015 - Wiley Online Library
Background and Purpose N a V 1.8 ion channels have been highlighted as important
molecular targets for the design of low MW blockers for the treatment of chronic pain. Here, we …

[HTML][HTML] Deubiquitylating enzymes and DNA damage response pathways

X Jacq, M Kemp, NMB Martin, SP Jackson - Cell biochemistry and …, 2013 - Springer
Covalent post-translational modification of proteins by ubiquitin and ubiquitin-like factors has
emerged as a general mechanism to regulate myriad intra-cellular processes. The addition …

Recent advances in the discovery of deubiquitinating enzyme inhibitors

M Kemp - Progress in medicinal chemistry, 2016 - Elsevier
This review examines the small molecules described over the past decade as inhibitors of any
of the approximately 100 human deubiquitinating enzymes (DUBs). Structures from patent …

[HTML][HTML] Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model

…, Y Sun, AC Pearce, S Eleuteri, M Kemp… - Nature …, 2023 - nature.com
Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson’s
disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic PD. This α-…

Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

…, MS Glossop, TL Hay, MI Kemp… - ACS medicinal …, 2015 - ACS Publications
Voltage-gated sodium channels, in particular Na v 1.8, can be targeted for the treatment of
neuropathic and inflammatory pain. Herein, we described the optimization of Na v 1.8 …

Modulation of the partition coefficient between octanol and buffer at pH 7.4 and pKa to achieve the optimum balance of blood clearance and volume of distribution for …

T Hay, R Jones, K Beaumont, M Kemp - Drug metabolism and disposition, 2009 - ASPET
The relationship between rat pharmacokinetics and physicochemical parameters [the partition
coefficient between octanol and buffer at pH 7.4 (log D (7.4) ) and pK a ] was studied for a …

Subtype‐specific actions of β‐amyloid peptides on recombinant human neuronal nicotinic acetylcholine receptors (α7, α4β2, α3β4) expressed in Xenopus laevis …

L Pym, M Kemp, V Raymond‐Delpech… - British journal of …, 2005 - Wiley Online Library
Two‐electrode voltage‐clamp electrophysiology has been used to study the actions of two
amyloid peptides (Aβ 1–42 , Aβ 1–40 ) on α7, α4β2 and α3β4 recombinant human neuronal …

[BOOK][B] Dixie lullaby: a story of music, race, and new beginnings in a new South

M Kemp - 2006 - books.google.com
… "Kemp's anecdotal and affectionate remembrance of … "Though surely too much of a southern
gentleman to admit it, Mark Kemp is … "Mark Kemp was part of the generation of young white …

Does the femoral offset affect replacements? The results from a National Joint Registry

MC Wyatt, DC Kieser, MA Kemp, G McHugh… - Hip …, 2019 - journals.sagepub.com
Background: Femoral component offset influences the torque forces exerted on a femoral
stem and may therefore adversely affect femoral component survival. This study investigated …