Metabolic activation of carboxylic acids
…, KG Madsen, SH Hansen, MP Grillo - Expert opinion on …, 2008 - Taylor & Francis
Background: Carboxylic acids constitute a large and heterogeneous class of both endogenous
and xenobiotic compounds. A number of carboxylic acid drugs have been associated …
and xenobiotic compounds. A number of carboxylic acid drugs have been associated …
Characterization of cytochrome P450 3A inactivation by cannabidiol: possible involvement of cannabidiol-hydroxyquinone as a P450 inactivator
LM Bornheim, MP Grillo - Chemical research in toxicology, 1998 - ACS Publications
Cannabidiol (CBD) is a major constituent of marijuana and a potent inhibitor of P450-mediated
hepatic drug metabolism. Mouse P450 3A11 metabolism of [ 14 C]CBD resulted in the …
hepatic drug metabolism. Mouse P450 3A11 metabolism of [ 14 C]CBD resulted in the …
In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin
MP Grillo, JCL Erve, R Dick, JP Driscoll, N Haste… - Xenobiotica, 2019 - Taylor & Francis
Mavacamten is a small molecule modulator of cardiac myosin designed as an orally administered
drug for the treatment of patients with hypertrophic cardiomyopathy. The current study …
drug for the treatment of patients with hypertrophic cardiomyopathy. The current study …
Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl-glutathione in rat bile
MP Grillo, CG Knutson, PE Sanders, DJ Waldon… - Drug metabolism and …, 2003 - ASPET
Diclofenac, a nonsteroidal anti-inflammatory drug, is metabolized to a reactive acyl glucuronide
that has been proposed to mediate toxic adverse drug reactions associated with its use. …
that has been proposed to mediate toxic adverse drug reactions associated with its use. …
Constituents in kava extracts potentially involved in hepatotoxicity: a review
LR Olsen, MP Grillo, C Skonberg - Chemical research in …, 2011 - ACS Publications
Aqueous kava root preparations have been consumed in the South Pacific as an apparently
safe ceremonial and cultural drink for centuries. However, several reports of hepatotoxicity …
safe ceremonial and cultural drink for centuries. However, several reports of hepatotoxicity …
Mechanistic Studies on the Bioactivation of Diclofenac: Identification of Diclofenac-S-acyl-glutathione in Vitro in Incubations with Rat and Human Hepatocytes
MP Grillo, F Hua, CG Knutson, JA Ware… - Chemical research in …, 2003 - ACS Publications
Diclofenac, a nonsteroidal anti-inflammatory drug, is metabolized to diclofenac-1-O-acyl
glucuronide (D-1-O-G), a chemically reactive conjugate that has been implicated as playing a …
glucuronide (D-1-O-G), a chemically reactive conjugate that has been implicated as playing a …
Detecting reactive drug metabolites for reducing the potential for drug toxicity
MP Grillo - Expert opinion on drug metabolism & toxicology, 2015 - Taylor & Francis
Introduction: A number of withdrawn drugs are known to undergo bioactivation by a range of
drug metabolizing enzymes to chemically reactive metabolites that bind covalently to …
drug metabolizing enzymes to chemically reactive metabolites that bind covalently to …
Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and-independent …
K Kassahun, P Hu, MP Grillo, MR Davis, L Jin… - Chemico-biological …, 1994 - Elsevier
The ability of 2-n-propyl-4-pentenoic acid (Δ 4 -VPA) and 2-n-propyl-2(E)-pentenoic acid ([E]-Δ
2 -VPA), two unsaturated metabolites of valproic acid (VPA), to form reactive intermediates…
2 -VPA), two unsaturated metabolites of valproic acid (VPA), to form reactive intermediates…
Effect of culture time on the basal expression levels of drug transporters in sandwich-cultured primary rat hepatocytes
…, JS Houghton, C Uyeda, MP Grillo… - Drug metabolism and …, 2011 - ASPET
Sandwich-cultured rat hepatocytes are used in drug discovery for pharmacological and
toxicological assessment of drug candidates, yet their utility as a functional model for drug …
toxicological assessment of drug candidates, yet their utility as a functional model for drug …
Studies on the Chemical Reactivity of 2-Phenylpropionic Acid 1-O-Acyl Glucuronide and S-Acyl-CoA Thioester Metabolites
C Li, LZ Benet, MP Grillo - Chemical research in toxicology, 2002 - ACS Publications
Chemically reactive species formed from the metabolism of carboxylic acid-containing
compounds have been proposed as mediators of their toxic side-effects. Two alternative …
compounds have been proposed as mediators of their toxic side-effects. Two alternative …