The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences

…, C Duret, M Daujat-Chavanieu… - Annu. Rev …, 2008 - annualreviews.org
The expression of many genes involved in xenobiotic/drug metabolism and transport is
regulated by at least three nuclear receptors or xenosensors: aryl hydrocarbon receptor (AhR), …

[HTML][HTML] Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

…, R Rahmani, V Cavaillès, M Daujat-Chavanieu… - Nature …, 2015 - nature.com
Humans are chronically exposed to multiple exogenous substances, including environmental
pollutants, drugs and dietary components. Many of these compounds are suspected to …

[PDF][PDF] A specific ChREBP and PPARα cross-talk is required for the glucose-mediated FGF21 response

…, E Tournier, M Do-Cruzeiro, M Daujat-Chavanieu… - Cell reports, 2017 - cell.com
While the physiological benefits of the fibroblast growth factor 21 (FGF21) hepatokine are
documented in response to fasting, little information is available on Fgf21 regulation in a …

Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes

…, A Ahluwalia, M DaujatChavanieu - Biotechnology …, 2011 - Wiley Online Library
Down‐regulation of detoxification genes, notably cytochrome P450 (CYPs), in primary hepatocyte
cultures is a long‐standing and major concern. We evaluated the influence of medium …

[HTML][HTML] Regulation of CAR and PXR Expression in Health and Disease

M Daujat-Chavanieu, S Gerbal-Chaloin - Cells, 2020 - mdpi.com
Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are
members of the nuclear receptor superfamily that mainly act as ligand-activated transcription …

Increased hepatic PDGF-AA signaling mediates liver insulin resistance in obesity-associated type 2 diabetes

…, A Leloire, M Pigeyre, M Daujat-Chavanieu… - Diabetes, 2018 - Am Diabetes Assoc
In type 2 diabetes (T2D), hepatic insulin resistance is strongly associated with nonalcoholic
fatty liver disease (NAFLD). In this study, we hypothesized that the DNA methylome of livers …

The WNT/β-catenin pathway is a transcriptional regulator of CYP2E1, CYP1A2, and aryl hydrocarbon receptor gene expression in primary human hepatocytes

…, J Ramos, P Maurel, M Daujat-Chavanieu - Molecular …, 2014 - ASPET
The wingless-type MMTV integration site family (WNT)/β-catenin/adenomatous polyposis coli
(CTNNB1/APC) pathway has been identified as a regulator of drug-metabolizing enzymes …

[HTML][HTML] Skatole (3-methylindole) is a partial aryl hydrocarbon receptor agonist and induces CYP1A1/2 and CYP1B1 expression in primary human hepatocytes

…, P Balaguer, B Ekstrand, M Daujat-Chavanieu… - PloS one, 2016 - journals.plos.org
Skatole (3-methylindole) is a product of bacterial fermentation of tryptophan in the intestine.
A significant amount of skatole can also be inhaled during cigarette smoking. Skatole is a …

Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane …

C Duret, M Daujat-Chavanieu, JM Pascussi… - Molecular …, 2006 - ASPET
The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) play a major
part in the control of drug metabolism and transport. We have previously shown that PXR …

[HTML][HTML] Impact of Alginate Composition: From Bead Mechanical Properties to Encapsulated HepG2/C3A Cell Activities for In Vivo Implantation

…, AV Salsac, P Paullier, M Daujat-Chavanieu… - PloS one, 2013 - journals.plos.org
<p>Recently, interest has focused on hepatocytes’ implantation to provide end stage liver
failure patients with a temporary support until spontaneous recovery or a suitable donor …