[PDF][PDF] Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were
outwardly identical to wild-type littermates. FXR/BAR null mice were distinguished from wild-type …
outwardly identical to wild-type littermates. FXR/BAR null mice were distinguished from wild-type …
Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides
M Miyata, JD Smith - Nature genetics, 1996 - nature.com
The apolipoprotein E (APOE) E4 allele is associated with Alzheimer's disease, cardiovascular
disease, and decreased longevity. To probe the mechanism of these associations, cell …
disease, and decreased longevity. To probe the mechanism of these associations, cell …
Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E.
…, C Grigaux, J Tian, M Miyata - Proceedings of the …, 1995 - National Acad Sciences
To develop a murine model system to test the role of monocyte-derived macrophage in
atherosclerosis, the osteopetrotic (op) mutation in the macrophage colony-stimulating factor gene …
atherosclerosis, the osteopetrotic (op) mutation in the macrophage colony-stimulating factor gene …
[HTML][HTML] Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation
Renal microsomal cytochrome P-450 monooxygenase-dependent metabolism of arachidonic
acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be further …
acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be further …
Cardiac involvement in mitochondrial diseases: a study on 17 patients with documented mitochondrial DNA defects
R Anan, M Nakagawa, M Miyata, I Higuchi, S Nakao… - Circulation, 1995 - Am Heart Assoc
Background Mutations of mitochondrial DNA have been demonstrated as causes of human
mitochondrial diseases. While these disorders typically involve multiple organs, the effect of …
mitochondrial diseases. While these disorders typically involve multiple organs, the effect of …
Grapefruit juice intake does not enhance but rather protects against aflatoxin B 1 -induced liver DNA damage through a reduction in hepatic CYP3A …
M Miyata, H Takano, LQ Guo, K Nagata… - …, 2004 - academic.oup.com
Influence of grapefruit juice intake on aflatoxin B 1 (AFB 1 )-induced liver DNA damage was
examined using a Comet assay in F344 rats given 5 mg/kg AFB 1 by gavage. Rats allowed …
examined using a Comet assay in F344 rats given 5 mg/kg AFB 1 by gavage. Rats allowed …
Clinical significance and reproducibility of new arterial distensibility index
T Kubozono, M Miyata, K Ueyama, A Nagaki… - Circulation …, 2007 - jstage.jst.go.jp
Background The brachial-ankle pulse wave velocity (baPWV) is used to evaluate the degree
of atherosclerosis and arterial distensibility, but its major limitation is that it is affected by …
of atherosclerosis and arterial distensibility, but its major limitation is that it is affected by …
Mechanism of recurrent/persistent ischemic/functional mitral regurgitation in the chronic phase after surgical annuloplasty: importance of augmented posterior leaflet …
…, T Yuasa, B Yu, T Uemura, K Takasaki, M Miyata… - Circulation, 2006 - Am Heart Assoc
Background— Surgical annuloplasty can potentially hoist the posterior annulus anteriorly,
exaggerate posterior leaflet (PML) tethering, and lead to recurrent ischemic/functional mitral …
exaggerate posterior leaflet (PML) tethering, and lead to recurrent ischemic/functional mitral …
Mechanism of 7, 12-dimethylbenz [a] anthracene-induced immunotoxicity: role of metabolic activation at the target organ
M Miyata, M Furukawa, K Takahashi… - The Japanese Journal …, 2001 - jstage.jst.go.jp
The polycyclic aromatic hydrocarbon, 7, 12-dimethylbenz [a] anthracene (DMBA), is an
immunosuppressor as well as a potent organ-specific carcinogen. To understand the organ-…
immunosuppressor as well as a potent organ-specific carcinogen. To understand the organ-…
Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia
Y Akasaki, M Miyata, H Eto, T Shirasawa… - Circulation …, 2006 - jstage.jst.go.jp
Background Nitric oxide (NO), constitutively produced by endothelial NO synthase (eNOS),
plays roles in angiogenesis. Having reported that thermal therapy up-regulated the …
plays roles in angiogenesis. Having reported that thermal therapy up-regulated the …