Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1
…, M Saeki, H Fukushima-Uesaka, M Itoda… - Drug metabolism and …, 2004 - jstage.jst.go.jp
Metabolic capacities for debrisoquin, sparteine, mephenytoin, nifedipine, and midazolam,
which are substrates of polymorphic CYP2D6, CYP2C19, and CYP3A, have been reported to …
which are substrates of polymorphic CYP2D6, CYP2C19, and CYP3A, have been reported to …
Functional analysis of SNPs variants of BCRP/ABCG2
C Kondo, H Suzuki, M Itoda, S Ozawa, J Sawada… - Pharmaceutical …, 2004 - Springer
Purpose. The aim of the current study was to identify the effect of single nucleotide
polymorphisms (SNPs) in breast cancer resistance protein (BCRP/ABCG2) on its localization, …
polymorphisms (SNPs) in breast cancer resistance protein (BCRP/ABCG2) on its localization, …
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan
K Sai, N Kaniwa, M Itoda, Y Saito… - Pharmacogenetics …, 2003 - journals.lww.com
We performed comprehensive haplotyping of ABCB1/MDR1 gene blocks using 49 genetic
polymorphisms, including seven novel ones, obtained from 145 Japanese subjects. The …
polymorphisms, including seven novel ones, obtained from 145 Japanese subjects. The …
Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2
M Hirouchi, H Suzuki, M Itoda, S Ozawa… - Pharmaceutical …, 2004 - Springer
Purpose. The presence of single nucleotide polymorphisms (SNPs) has been reported for
multidrug resistance-associated protein 2 (MRP2/ABCC2). The purpose of the current study …
multidrug resistance-associated protein 2 (MRP2/ABCC2). The purpose of the current study …
Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver
…, N Hanioka, S Ishida, M Saeki, A Soyama, M Itoda… - Molecular …, 2004 - ASPET
Human constitutive androstane (or active) receptor (hCAR), a member of the nuclear receptor
superfamily NR1I3, regulates the expression of several genes that are mainly involved in …
superfamily NR1I3, regulates the expression of several genes that are mainly involved in …
Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: an association between single nucleotide …
M Itoda, Y Saito, A Soyama, M Saeki… - Drug metabolism and …, 2002 - ASPET
We found nucleotide variability in the 5′-upstream region and exonic sequences of a gene-encoding
canalicular multispecific organic anion transporter/multidrug resistance-…
canalicular multispecific organic anion transporter/multidrug resistance-…
CYP3A4 gene polymorphisms influence testosterone 6β-hydroxylation
…, Y Saito, K Sai, S Ishida, O Nakajima, M Itoda… - Drug metabolism and …, 2002 - Elsevier
Three non-synonymous single nucleotide polymorphisms (SNPs) in the CYP3A4 gene were
found in 34 cell lines derived from Japanese individuals. These three SNPs (T185S, L293P, …
found in 34 cell lines derived from Japanese individuals. These three SNPs (T185S, L293P, …
Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1)
M Itoda, Y Saito, K Maekawa, H Hichiya… - Drug metabolism and …, 2004 - jstage.jst.go.jp
Twenty genetic variations, including seven novel ones, were found in the human SLC22A1
gene, which encodes organic cation transporter 1, from 116 Japanese individuals. The novel …
gene, which encodes organic cation transporter 1, from 116 Japanese individuals. The novel …
Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan
M Itoda, Y Saito, K Shirao, H Minami… - Drug metabolism and …, 2003 - jstage.jst.go.jp
Eight novel single nucleotide polymorphisms (SNPs) were found in the gene encoding the
ATP-binding cassette transporter, ABCG2WBCRP, from 60 Japanese individuals …
ATP-binding cassette transporter, ABCG2WBCRP, from 60 Japanese individuals …
Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population
K Maekawa, M Itoda, K Sai, Y Saito… - Drug metabolism and …, 2006 - jstage.jst.go.jp
The ATPbinding cassette transporter, ABCG2, which is expressed at high levels in the
intestine and liver, functions as an effiux transporter for many drugs, including clinically used …
intestine and liver, functions as an effiux transporter for many drugs, including clinically used …