Tissue-specific mRNA expression profiles of human toll-like receptors and related genes
M Nishimura, S Naito - Biological and Pharmaceutical Bulletin, 2005 - jstage.jst.go.jp
MATERIALS AND METHODS Materials Total RNA prepared from pooled specimens of fetal
human tissues (brain and liver), from single and pooled specimens of adult human tissues (…
human tissues (brain and liver), from single and pooled specimens of adult human tissues (…
Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies
M Nishimura, S Naito - Drug metabolism and pharmacokinetics, 2005 - jstage.jst.go.jp
Pairs of forward and reverse primers and TaqMan probes speciˆc to each of 46 human ATP-binding
cassette (ABC) transporters and 108 human solute carrier (SLC) transporters were …
cassette (ABC) transporters and 108 human solute carrier (SLC) transporters were …
Tissue distribution of MRNA expression of human cytochrome P450 isoforms assessedby high-sensitivity real-time reverse transcription PCR
M Nishimura, H Yaguti, H Yoshitsugu, S Naito… - Yakugaku …, 2003 - jstage.jst.go.jp
Pairs of forward and reverse primers and TaqMan probes specific to each human cytochrome
P450 isoform were prepared. Analysis of the mRNA level of each CYP isoform in total RNA …
P450 isoform were prepared. Analysis of the mRNA level of each CYP isoform in total RNA …
Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes
M Nishimura, S Naito - Drug metabolism and pharmacokinetics, 2006 - jstage.jst.go.jp
Pairs of forward and reverse primers and TaqMan probes specific to each of 52 human
phase I metabolizing enzymes (alcohol dehydrogenase, aldehyde dehydrogenase, aldehyde …
phase I metabolizing enzymes (alcohol dehydrogenase, aldehyde dehydrogenase, aldehyde …
[HTML][HTML] Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice
…, K Ishizaka, S Shioda, S Arata, M Nishimura… - Journal of Biological …, 2009 - ASBMB
Phospholipid hydroperoxide glutathione peroxidase (GPx4) is an intracellular antioxidant
enzyme that directly reduces peroxidized phospholipids. GPx4 is strongly expressed in the …
enzyme that directly reduces peroxidized phospholipids. GPx4 is strongly expressed in the …
Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies
M Nishimura, S Naito, T Yokoi - Drug metabolism and pharmacokinetics, 2004 - Elsevier
Pairs of forward and reverse primers and TaqMan probes specific to each human nuclear
receptor were prepared. Analysis of the mRNA expression level of each target of 43 nuclear …
receptor were prepared. Analysis of the mRNA expression level of each target of 43 nuclear …
Tissue-specific mRNA expression profiles of human solute carrier transporter superfamilies
M Nishimura, S Naito - Drug metabolism and pharmacokinetics, 2008 - Elsevier
Pairs of forward and reverse primers and TaqMan probes specific to each of 173 human
solute carrier (SLC) transporters were prepared. The mRNA expression level of each target …
solute carrier (SLC) transporters were prepared. The mRNA expression level of each target …
CYP2C19 genotype affects diazepam pharmacokinetics and emergence from general anesthesia
…, F Itagaki, M Homma, M Nishimura… - Clinical …, 2005 - Wiley Online Library
Objectives Diazepam is widely used to relieve preoperative anxiety in patients. The objective
of this study was to investigate the effects of polymorphism in CYP2C19 and the effects of …
of this study was to investigate the effects of polymorphism in CYP2C19 and the effects of …
Expression of human phase II enzymes in chimeric mice with humanized liver
…, T Matsui, H Okumura, M Nakajima, M Nishimura… - Drug Metabolism and …, 2005 - ASPET
We clarified that major human cytochrome P450 (P450) enzymes were expressed in a chimeric
mouse line established recently in Japan, in which the liver could be replaced by more …
mouse line established recently in Japan, in which the liver could be replaced by more …
Cytochrome P450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver
M Furukawa, M Nishimura, D Ogino, R Chiba… - Cancer …, 2004 - Wiley Online Library
Cytochromes P450 (CYPs) compose a superfamily of similar proteins involved in detoxification
and elimination, as well as activation of a wide variety of compounds. Most CYP family …
and elimination, as well as activation of a wide variety of compounds. Most CYP family …