Developmental expression of the major human hepatic CYP3A enzymes

…, JR Manro, PJ Tandler, MJ Zaya - … of Pharmacology and …, 2003 - ASPET
The human cytochrome P4503A forms show expression patterns subject to developmental
influence. CYP3A7 and CYP3A4 are generally classified as the major fetal and adult liver …

Developmental changes in human liver CYP2D6 expression

JC Stevens, SA Marsh, MJ Zaya, KJ Regina… - Drug metabolism and …, 2008 - ASPET
Within the human cytochrome P450 family, specific forms show developmental expression
patterns that can affect drug clearance, efficacy, and safety. The objective of this study was to …

Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens

…, JG Slatter, JP Sams, NL Oien, MJ Zaya… - Journal of medicinal …, 2003 - ACS Publications
A new and promising group of antibacterial agents, collectively known as the oxazolidinones
and exemplified by linezolid (PNU-100766, marketed as Zyvox), have recently emerged as …

Epirubicin glucuronidation and UGT2B7 developmental expression

MJ Zaya, RN Hines, JC Stevens - Drug Metabolism and Disposition, 2006 - ASPET
The usefulness of epirubicin in the treatment of adult and childhood malignant diseases is
related in part to the potential reduction in cardiac toxicity compared with that of other …

In vitro drug-drug interaction screens for canine veterinary medicines: evaluation of cytochrome P450 reversible inhibition

D Aidasani, MJ Zaya, PB Malpas… - Drug metabolism and …, 2008 - ASPET
Little information regarding the metabolic pathways of pharmaceutical agents administered
to dogs, or the inhibition of those metabolic pathways, is available. Without this information, it …

Dopamine D3 Receptor Antagonists. 1. Synthesis and Structure−Activity Relationships of 5,6-Dimethoxy-N-alkyl- and N-Alkylaryl-Substituted 2-Aminoindans

…, MW Smith, KA Svensson, MJ Zaya… - Journal of medicinal …, 2001 - ACS Publications
5,6-Dimethoxy-2-(N-dipropyl)-aminoindan (3, PNU-99194A) was found to be a selective
dopamine D 3 receptor antagonist with potential antipsychotic properties in animal models. To …

Disposition of ceftiofur sodium in swine following intramuscular treatment

…, RD Roof, JL Nappier, MJ Zaya… - Journal of Agricultural …, 1995 - ACS Publications
Ceftiofur displays a broad spectrum of bactericidal activity against both Gram-positiveand
Gramnegative bacteria including/3-lactamase-producing strains. Three to fivemilligrams of …

Current cytochrome P450 phenotyping methods applied to metabolic drug-drug interaction prediction in dogs

BM Mills, MJ Zaya, RR Walters, KL Feenstra… - Drug metabolism and …, 2010 - ASPET
Recombinant cytochrome P450 (P450) phenotyping, different approaches for estimating
fraction metabolized (f m ), and multiple measures of in vivo inhibitor exposure were tested for …

Expression and characterization of functional dog flavin-containing monooxygenase 1

JC Stevens, RJ Melton, MJ Zaya, LC Engel - Molecular pharmacology, 2003 - ASPET
A full-length dog (beagle) flavin-containing monooxygenase 1 (FMO1) cDNA (dFMO1) was
obtained from liver by reverse transcription-polymerase chain reaction. The amino acid …

The Penetration Enhancer SEPATM Augments Stimulation of Scalp Hair Growth by Topical Minoxidil in the Balding Stumptail Macaque

AR Diani, KL Skull, MJ Zaya, MN Brunden - Skin Pharmacology and …, 1995 - karger.com
The purpose of this study was to determine if the penetration enhancer SEPA TM (2-n-nonyl-1,3-dioxolane)
would augment the scalp hair growth effects of topical minoxidil in the …