Vaccine hesitancy and emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern (VOCs) escaping vaccine-induced immune responses …

Buprenorphine is the cornerstone of pain management in nonhuman primates, but the
pharmacokinetics of this widely used drug are unknown. The purpose of this study was to …

In a mass casualty radiation event situation, individualized therapy may overwhelm
available resources and feasibility issues suggest a need for the development of population-based …

Background: Angiotensin-converting enzyme (ACE) is highly expressed in renal proximal
tubules, but ACE activity/levels in the urine are at least 100-fold lower than in the blood. …

The development of effective biomarkers for detecting the magnitude of radiation exposure
and resiliency of host response is crucial to identifying appropriate treatment strategies after …

Aspirin is one of the oldest drugs and has been purported to have multiple beneficial effects,
including prevention of cardiovascular disease and cancer, in addition to its original …

Administration of high dose vitamin K 1 (VK 1 ) overcomes coagulopathy and bleeding elicited
by acute poisoning with long-acting anti-coagulant rodenticides (LAARs). However, long-…

In rodent studies, the gut microbiota has been implicated in facilitating both radioresistance,
by protecting the epithelium from apoptotic responses and radiosensitivity, inducing …

Brodifacoum (BDF) is a potent, long-acting anticoagulant rodenticide that can cause fatal
poisoning in humans. The chemical structure of BDF includes 2 chiral carbons, resulting in 2 …

Opioids are widely used in veterinary and human medicine to manage pain. However, there
is a paucity of information in the literature regarding the pharmacokinetics of opioid …