Background Studies examining sex differences in CYP3A activity have produced conflicting
results. Our objective is to investigate whether sex differences exist in CYP3A activity as …

Intercellular exchange of protein and RNA-containing microparticles is an increasingly
important mode of cell–cell communication. Here we investigate if mesenchymal stem cells (MSCs…

Variable interindividual expression of cytochrome P450 3A presents a challenge in dosing
drugs. The use of potent inhibitors of CYP3A such as ketoconazole has been explored to …

Retinoids are differentiating agents that have been used successfully for the treatment of
acute promyelocytic leukemia. When combined with interferons, they are active in preventing …

Publisher Summary This chapter reviews the pharmacological differences between men
and women. There is a higher rate of medication use among women and different adverse …

Replication of human immunodeficiency virus type 1 (HIV‐1) in non‐dividing cells critically
depends on import of the viral pre‐integration complex into the nucleus. Genetic evidence …

The activation of p53 has been proposed as a novel anti-cancer treatment in two distinct
contexts. In the first activation of p53 in tumor cells can promote apoptosis and senescence and …

Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by bcr-abl1, a
constitutively active tyrosine kinase fusion gene responsible for an abnormal proliferation of …

C/EBPβ, a member of the CCAAT/enhancer binding protein (C/EBP) family, is one of the key
transcription factors responsible for the induction of a wide array of genes, some of which …

Inhibitors of the mitotic kinase PLK1 yield objective responses in a subset of refractory cancers.
However, PLK1 overexpression in cancer does not correlate with drug sensitivity, and the …